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Paternal inheritance of mitochondrial DNA in mice

Naturevolume 352pages255257 (1991) | Download Citation

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Abstract

FOR nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals1. Using the polymerase chain reaction2, 3, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10−4, relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.

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References

  1. 1

    Gyllensten, U., Wharton, D. & Wilson, A. C. J. Hered. 76, 321–324 (1985).

  2. 2

    Mullis, K. B. & Faloona, F. Meth. Enzym. 155, 335–350 (1987).

  3. 3

    Saiki, R. K. et al. Science 239, 487–491 (1988).

  4. 4

    Tsuzuki, T., Nomiyama, H., Setoyama, C., Maeda, S. & Shimada, K. Gene 25, 223–229 (1983).

  5. 5

    Gilliland, G., Perrin, S. & Bunn, H. F. in PCR Protocols. A Guide to Methods and Applications (eds Innis, M. A., Gelfand, D. H., Sninsky, J. J. & White, T. J.) 60–69 (Academic, New York. 1990).

  6. 6

    Hecht, N. B., Liem, H., Kleene, K. C., Distel, R. J. & Ho, S.-M. Devl Biol. 102, 452–461 (1984).

  7. 7

    Michaels, G. S., Hauswirth, W. W. & Laipis, P. J. Devl Biol 94, 246–251 (1982).

  8. 8

    Kondo, R. et al. Genetics 126, 657–663 (1990).

  9. 9

    Hoeh, W. R., Blakley, K. H. & Brown, W. M. Science 251, 1488–1490 (1991).

  10. 10

    Ferris, S. D., Sage, R. D., Prager, E. M., Ritte, U. & Wilson, A. C. Genetics 105, 681–721 (1983).

  11. 11

    Olivo, P. D., Van de Walle, M. J., Laipis, P. J. & Hauswirth, W. W. Nature 306, 400–402 (1983).

  12. 12

    Solignac, M., Génermont, J., Monnerot, M. & Mounolou, J.-C. Molec. gen. Genet. 197, 183–188 (1984).

  13. 13

    Holt, I. J., Harding, A. E. & Morgan-Hughes, J. A. Nature 331, 717–719 (1988).

  14. 14

    Moraes, C. T. et al. New Engl. J. Med. 320, 1293–1299 (1989).

  15. 15

    Hauswirth, W. W. & Laipis, P. J. Proc. natn. Acad. Sci. U.S.A. 79, 4686–4690 (1982).

  16. 16

    Cann, R. L., Stoneking, M. & Wilson, A. C. Nature 325, 31–36 (1987).

  17. 17

    Bibb, M. J., Van Etten, R. A., Wright, C. T., Walberg, M. W. & Clayton, D. A. Cell 26, 167–180 (1981).

  18. 18

    Gyllensten, U. B. & Erlich, H. A. Proc. natn. Acad. Sci. U.S.A. 85, 7652–7656 (1988).

  19. 19

    Bishop, C. E., Boursot, P., Baron, B., Bonhomme, F. & Hatat, D. Nature 315, 70–72 (1985).

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Affiliations

  1. Department of Medical Genetics, Biomedical Center, University of Uppsala, Box 589, S-751 23, Uppsala, Sweden

    • Ulf Gyllensten
    •  & Agneta Josefsson
  2. New York Zoological Society, Bronx Zoo, New York, 10460

    • Dan Wharton
  3. Department of Biological Sciences, Fordham University, Bronx, New York, 10458, USA

    • Dan Wharton
  4. Division of Biochemistry and Molecular Biology, University of California, Berkeley, California, 94720, USA

    • Allan C. Wilson

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https://doi.org/10.1038/352255a0

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