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Paternal inheritance of mitochondrial DNA in mice

Nature volume 352, pages255–257(1991)Cite this article

Abstract

FOR nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals1. Using the polymerase chain reaction2, 3, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10−4, relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.

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References

  1. 1

    Gyllensten, U., Wharton, D. & Wilson, A. C. J. Hered. 76, 321–324 (1985).

    CAS  Article  Google Scholar 

  2. 2

    Mullis, K. B. & Faloona, F. Meth. Enzym. 155, 335–350 (1987).

    CAS  Article  Google Scholar 

  3. 3

    Saiki, R. K. et al. Science 239, 487–491 (1988).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Tsuzuki, T., Nomiyama, H., Setoyama, C., Maeda, S. & Shimada, K. Gene 25, 223–229 (1983).

    CAS  Article  Google Scholar 

  5. 5

    Gilliland, G., Perrin, S. & Bunn, H. F. in PCR Protocols. A Guide to Methods and Applications (eds Innis, M. A., Gelfand, D. H., Sninsky, J. J. & White, T. J.) 60–69 (Academic, New York. 1990).

    Google Scholar 

  6. 6

    Hecht, N. B., Liem, H., Kleene, K. C., Distel, R. J. & Ho, S.-M. Devl Biol. 102, 452–461 (1984).

    CAS  Article  Google Scholar 

  7. 7

    Michaels, G. S., Hauswirth, W. W. & Laipis, P. J. Devl Biol 94, 246–251 (1982).

    CAS  Article  Google Scholar 

  8. 8

    Kondo, R. et al. Genetics 126, 657–663 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. 9

    Hoeh, W. R., Blakley, K. H. & Brown, W. M. Science 251, 1488–1490 (1991).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Ferris, S. D., Sage, R. D., Prager, E. M., Ritte, U. & Wilson, A. C. Genetics 105, 681–721 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. 11

    Olivo, P. D., Van de Walle, M. J., Laipis, P. J. & Hauswirth, W. W. Nature 306, 400–402 (1983).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Solignac, M., Génermont, J., Monnerot, M. & Mounolou, J.-C. Molec. gen. Genet. 197, 183–188 (1984).

    CAS  Article  Google Scholar 

  13. 13

    Holt, I. J., Harding, A. E. & Morgan-Hughes, J. A. Nature 331, 717–719 (1988).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Moraes, C. T. et al. New Engl. J. Med. 320, 1293–1299 (1989).

    CAS  Article  Google Scholar 

  15. 15

    Hauswirth, W. W. & Laipis, P. J. Proc. natn. Acad. Sci. U.S.A. 79, 4686–4690 (1982).

    ADS  CAS  Article  Google Scholar 

  16. 16

    Cann, R. L., Stoneking, M. & Wilson, A. C. Nature 325, 31–36 (1987).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Bibb, M. J., Van Etten, R. A., Wright, C. T., Walberg, M. W. & Clayton, D. A. Cell 26, 167–180 (1981).

    CAS  Article  Google Scholar 

  18. 18

    Gyllensten, U. B. & Erlich, H. A. Proc. natn. Acad. Sci. U.S.A. 85, 7652–7656 (1988).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Bishop, C. E., Boursot, P., Baron, B., Bonhomme, F. & Hatat, D. Nature 315, 70–72 (1985).

    ADS  CAS  Article  Google Scholar 

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Author information

Affiliations

  1. Department of Medical Genetics, Biomedical Center, University of Uppsala, Box 589, S-751 23, Uppsala, Sweden

    Ulf Gyllensten & Agneta Josefsson

  2. New York Zoological Society, Bronx Zoo, New York, 10460

    Dan Wharton

  3. Department of Biological Sciences, Fordham University, Bronx, New York, 10458, USA

    Dan Wharton

  4. Division of Biochemistry and Molecular Biology, University of California, Berkeley, California, 94720, USA

    Allan C. Wilson

Authors
  1. Ulf Gyllensten
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  2. Dan Wharton
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  3. Agneta Josefsson
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  4. Allan C. Wilson
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Gyllensten, U., Wharton, D., Josefsson, A. et al. Paternal inheritance of mitochondrial DNA in mice. Nature 352, 255–257 (1991). https://doi.org/10.1038/352255a0

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