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Two different microtubule-based motor activities with opposite polarities in kinetochores

Abstract

The movement of microtubules on the kinetochores of isolated chromosomes has been examined by video microscopy. Two different microtubule-based motors on the kinetochore were identified, which have opposite directions of movement. The activities of these two motors can be regulated by factors that can influence phosphorylation.

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Hyman, A., Mitchison, T. Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature 351, 206–211 (1991). https://doi.org/10.1038/351206a0

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