Brief Communication

Longevity: Extending the lifespan of long-lived mice

Published:

Abstract

Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings1,2,3 because they carry a 'longevity' gene, Prop1df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake2,4,5. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.

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Author information

Affiliations

  1. *Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois 62901, USA

    • Andrzej Bartke
    •  & J. Chris Wright
  2. †National Institute on Aging, NIH Animal Center, 16701 Elmer School Road, Poolesville, Maryland 20837, USA

    • Julie A. Mattison
    •  & Donald K. Ingram
  3. ‡University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA

    • Richard A. Miller
  4. §Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA

    • George S. Roth

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Corresponding author

Correspondence to Andrzej Bartke.

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