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Interocular rivalry revealed in the human cortical blind-spot representation

Abstract

To understand conscious vision, scientists must elucidate how the brain selects specific visual signals for awareness. When different monocular patterns are presented to the two eyes, they rival for conscious expression such that only one monocular image is perceived at a time1,2. Controversy surrounds whether this binocular rivalry reflects neural competition among pattern representations or monocular channels3,4. Here we show that rivalry arises from interocular competition, using functional magnetic resonance imaging of activity in a monocular region of primary visual cortex corresponding to the blind spot. This cortical region greatly prefers stimulation of the ipsilateral eye to that of the blind-spot eye. Subjects reported their dominant percept while viewing rivalrous orthogonal gratings in the visual location corresponding to the blind spot and its surround. As predicted by interocular rivalry, the monocular blind-spot representation was activated when the ipsilateral grating became perceptually dominant and suppressed when the blind-spot grating became dominant. These responses were as large as those observed during actual alternations between the gratings, indicating that rivalry may be fully resolved in monocular visual cortex. Our findings provide the first physiological evidence, to our knowledge, that interocular competition mediates binocular rivalry, and indicate that V1 may be important in the selection and expression of conscious visual information.

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Figure 1: Localization of the V1 blind-spot representation.
Figure 2: Binocular rivalry and stimulus alternation tasks.
Figure 3: MRI activity during rivalry and stimulus alternation.
Figure 4: MRI response amplitudes for rivalry versus stimulus alternation.

References

  1. Helmholtz, H. v. Helmholtz's Treatise on Physiological Optics (The Optical Society of America, Rochester, New York, 1924).

    Google Scholar 

  2. Levelt, W. J. M. On Binocular Rivalry (Royal VanGorcum, Assen, The Netherlands, 1965).

    Google Scholar 

  3. Blake, R. A neural theory of binocular rivalry. Psychol. Rev. 96, 145–167 (1989).

    CAS  Article  Google Scholar 

  4. Leopold, D. A. & Logothetis, N. K. Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry. Nature 379, 549–553 (1996).

    ADS  CAS  Article  Google Scholar 

  5. Logothetis, N. K. & Schall, J. D. Neural correlates of subjective visual perception. Science 245, 761–763 (1989).

    ADS  CAS  Article  Google Scholar 

  6. Sheinberg, D. L. & Logothetis, N. K. The role of temporal cortical areas in perceptual organization. Proc. Natl Acad. Sci. USA 94, 3408–3413 (1997).

    ADS  CAS  Article  Google Scholar 

  7. Tootell, R. B. H. et al. Functional analysis of primary visual cortex (V1) in humans. Proc. Natl Acad. Sci. USA 95, 811–817 (1998).

    ADS  CAS  Article  Google Scholar 

  8. Tong, F., Nakayama, K., Vaughan, J. T. & Kanwisher, N. Binocular rivalry and visual awareness in human extrastriate cortex. Neuron 21, 753–759 (1998).

    CAS  Article  Google Scholar 

  9. Walls, G. L. The filling in process. Am. J. Optom. Arch. Am. Acad. Optom. 31, 329–341 (1954).

    CAS  Article  Google Scholar 

  10. Stensaas, S. S., Eddington, D. K. & Dobelle, W. H. The topography and variability of the primary visual cortex in man. J. Neurosurg. 40, 747–755 (1974).

    CAS  Article  Google Scholar 

  11. Fox, R. & Rasche, F. Binocular rivalry and reciprocal inhibition. Percept. Psychophys. 5, 215–217 (1969).

    Article  Google Scholar 

  12. Lehky, S. R. An astable multivibrator model of binocular rivalry. Perception 17, 215–228 (1988).

    CAS  Article  Google Scholar 

  13. Polonsky, A., Blake, R., Braun, J. & Heeger, D. J. Neuronal activity in human primary visual cortex correlates with perception during binocular rivalry. Nature Neurosci. 3, 1153–1159 (2000).

    CAS  Article  Google Scholar 

  14. Lansing, R. W. Electroencephalographic correlates of binocular rivalry in man. Science 146, 1325–1327 (1964).

    ADS  CAS  Article  Google Scholar 

  15. Cobb, W. A., Morton, H. B. & Ettlinger, G. Cerebral potential evoked by pattern reversal and their suppression in visual rivalry. Nature 216, 1123–1125 (1967).

    ADS  CAS  Article  Google Scholar 

  16. Brown, R. J. & Norcia, A. M. A method for investigating binocular rivalry in real-time with the steady-state VEP. Vision Res. 37, 2401–2408 (1997).

    CAS  Article  Google Scholar 

  17. Tononi, G., Srinivasan, R., Russell, D. P. & Edelman, G. M. Investigating neural correlates of conscious perception by frequency-tagged neuromagnetic responses. Proc. Natl Acad. Sci. USA 95, 3198–3203 (1998).

    ADS  CAS  Article  Google Scholar 

  18. Lumer, E. D., Friston, K. J. & Rees, G. Neural correlates of perceptual rivalry in the human brain. Science 280, 1930–1934 (1998).

    ADS  CAS  Article  Google Scholar 

  19. Wade, N. J. Monocular and binocular rivalry between contours. Perception 4, 85–95 (1975).

    CAS  Article  Google Scholar 

  20. Logothetis, N. K., Leopold, D. A. & Sheinberg, D. L. What is rivalling during binocular rivalry? Nature 380, 621–624 (1996).

    ADS  CAS  Article  Google Scholar 

  21. Lee, S. H. & Blake, R. Rival ideas about binocular rivalry. Vision Res. 39, 1447–1454 (1999).

    CAS  Article  Google Scholar 

  22. Andrews, T. J. & Purves, D. Similarities in normal and binocularly rivalrous viewing. Proc. Natl Acad. Sci. USA 94, 9905–9908 (1997).

    ADS  CAS  Article  Google Scholar 

  23. Crick, F. & Koch, C. Are we aware of neural activity in primary visual cortex? Nature 375, 121–123 (1995).

    ADS  CAS  Article  Google Scholar 

  24. Friston, K. J. et al. Statistical parametric maps in functional imaging: A general linear approach. Hum. Brain Mapp. 2, 189–210 (1994).

    Article  Google Scholar 

Download references

Acknowledgements

We thank A. Seiffert and K. Nakayama for comments on this manuscript; D. Tran for research assistance; and J. Mazziotta, M. Cohen, the UCLA Brain Mapping Medical Organization, the Ahmanson Foundation, the Pierson-Lovelace Foundation, the Tamkin Foundation, and the Jennifer Jones-Simon Foundation for support. This research was funded by a McDonnell-Pew Grant in Cognitive Neuroscience and by the National Institutes of Health.

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Correspondence to Frank Tong.

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Tong, F., Engel, S. Interocular rivalry revealed in the human cortical blind-spot representation. Nature 411, 195–199 (2001). https://doi.org/10.1038/35075583

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