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The myosin swinging cross-bridge model

Nature Reviews Molecular Cell Biology volume 2, pages 387–392 (2001)Cite this article

Abstract

No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have all made their contributions, and myosin is now becoming one of the best-understood enzymes in biology.

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Figure 1: The swinging cross-bridge model.
Figure 2: Prestroke and poststroke states of subfragment 1.
Figure 3: The actin-activated myosin-II ATPase cycle.
Figure 4: Predicted structure of myosin V.
Figure 5: Experimental scheme of the force-feedback-enhanced laser trap.
Figure 6: Nucleotide-dependent processive stepping of myosin V along an actin filament.

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Authors and Affiliations

  1. Department of Biochemistry and Department of Developmental Biology, Beckman Center, B400, Stanford University School of Medicine, Stanford, 94305-5307, California, USA

    James A. Spudich

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  1. James A. Spudich
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DATABASE LINKS

myosin

kinesin family

myosin II

myosin V

ENCYCLOPEDIA OF LIFE SCIENCES

Motor proteins

Actin and actin filaments

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Spudich, J. The myosin swinging cross-bridge model. Nat Rev Mol Cell Biol 2, 387–392 (2001). https://doi.org/10.1038/35073086

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