The myosin swinging cross-bridge model


No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have all made their contributions, and myosin is now becoming one of the best-understood enzymes in biology.

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Figure 1: The swinging cross-bridge model.
Figure 2: Prestroke and poststroke states of subfragment 1.
Figure 3: The actin-activated myosin-II ATPase cycle.
Figure 4: Predicted structure of myosin V.
Figure 5: Experimental scheme of the force-feedback-enhanced laser trap.
Figure 6: Nucleotide-dependent processive stepping of myosin V along an actin filament.


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kinesin family

myosin II

myosin V


Motor proteins

Actin and actin filaments

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Spudich, J. The myosin swinging cross-bridge model. Nat Rev Mol Cell Biol 2, 387–392 (2001).

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