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A viable herd of genetically uniform cattle

Naturevolume 409page303 (2001) | Download Citation

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  • An Erratum to this article was published on 01 March 2001

Deleterious alleles seem to have been purged in a feral strain of inbred cows.

Abstract

Inbreeding, which can lead to the loss of genetic variation or the accumulation of deleterious alleles, has been shown to reduce fitness in wild1, zoo, laboratory2 and farmed3 animals. But it has been proposed that when combined with selection, inbreeding may purge deleterious alleles4. Here we provide support for this hypothesis in a study of the Chillingham cattle, which shows that this viable herd is almost genetically uniform. The homozygosity of this herd far exceeds that of other cattle5 and that found in wild populations of other mammalian species6,7.

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References

  1. 1

    Saccheri, I. et al. Nature 392, 491–494 (1998).

  2. 2

    Frankham, R. & Ralls, K. Nature 392, 441–442 (1998).

  3. 3

    Wiener, G., Lee, G. J. & Woolliams, J. A. Anim. Prod. 55, 89– 99 (1992).

  4. 4

    Lacy, R. C. & Ballou, J. D. Evolution 52, 900–909 (1998).

  5. 5

    MacHugh, D. E., Loftus, R. T., Bradley, D. G., Sharp, P. M. & Cunningham, E. P. Proc. R. Soc. Lond. B 256, 25–31 (1994).

  6. 6

    Manotti-Raymond, M. A. & O'Brien, S. J. J. Hered. 86, 319–322 (1995).

  7. 7

    Goodman, S. J. Mol. Biol. Evol. 15, 104–118 (1998).

  8. 8

    Hall, S. J. G. & Hall, J. G. J. Zool. 216, 479–493 (1988).

  9. 9

    Paterson, S., Wilson, K. & Pemberton, J. M. Proc. Natl Acad. Sci. USA 95, 3714–3719 (1998).

  10. 10

    Caballero, A. Heredity 73, 657–679 ( 1994).

  11. 11

    Kimura, M. Proc. Natl Acad. Sci. USA 41, 144– 150 (1955).

  12. 12

    Stam, P. Genet. Res. 35, 131–155 (1980).

  13. 13

    Anderson, C. Nature 355, 382 (1992).

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Author information

Affiliations

  1. Roslin Institute, Roslin , EH25 9PS, UK

    • D. Smith
    •  & J. L. Williams
  2. School of Agriculture, De Montfort University, Caythorpe Court, Grantham, NG32 3EP, UK

    • S. J. G. Hall
  3. Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, UK

    • P. M. Visscher

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Correspondence to P. M. Visscher.

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https://doi.org/10.1038/35053160

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