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Cancer

Death and methylation

Nature volume 409, pages 141–143 (2001)Cite this article

Malignant melanoma cells can resist committing suicide when attacked by chemotherapy. The explanation lies in the discovery that a key gene in the cell-death pathway is switched off in this cancer.

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Figure 1: The p53-mediated death pathway, and how it can be subverted by DNA methylation.

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  1. USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, 90089-9181, California, USA

    Peter A. Jones

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  1. Peter A. Jones
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Correspondence to Peter A. Jones.

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Jones, P. Death and methylation. Nature 409, 141–143 (2001). https://doi.org/10.1038/35051677

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