Development

DNA methylation in Drosophila melanogaster

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Abstract

Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception1,2,3,4, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well5,6,7,9. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.

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Figure 1: Methylation analysis of Drosophila genomic DNA from wild-type (Oregon R) flies.

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Correspondence to Rudolf Jaenisch.

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