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Gene regulation

Local or global?

Modifications to histone proteins were thought to act only locally to control the expression of single genes. But the finding of such changes across the whole genome brings that view into question.

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Figure 1: A commonly held view of gene regulation.
Figure 2: Processes that might be regulated by the base level of histone acetylation discovered by Vogelauer et al.1 throughout the Saccharomyces cerevisiae genome.


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Correspondence to Shelley L. Berger.

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Berger, S. Local or global?. Nature 408, 412–415 (2000).

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