Signal transduction

A most interesting factor

Article metrics

The effects of the signalling molecule MIF are quite well understood, but how it works remains a mystery. Some of the pathways behind its activity have now been revealed — with surprising results.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Pathways by which MIF (macrophage migration inhibitory factor) may regulate inflammation and the proliferation of target cells.

References

  1. 1

    Kleemann, R. et al. Nature 408, 211–216 (2000).

  2. 2

    Weiser, W. Y. et al. Proc. Natl Acad. Sci. USA 86, 7522– 7526 (1989).

  3. 3

    Calandra, T. et al. Nature 377, 68–71 (1995).

  4. 4

    Bernhagen, J. et al. Nature 365, 756–759 (1993).

  5. 5

    Bacher, M. et al. Proc. Natl Acad. Sci. USA 93, 7849– 7854 (1996).

  6. 6

    Waeber, G. et al. Proc. Natl Acad. Sci. USA 94, 4782– 4787 (1997).

  7. 7

    Benigni, F. et al. J. Clin. Invest. (in the press).

  8. 8

    Swope, M. D. & Lolis, E. Rev. Physiol. Biochem. Pharmacol. 139, 1–32 ( 1999).

  9. 9

    Bendrat, K. et al. Biochemistry 36, 15356– 15362 (1997).

  10. 10

    Hermanowski-Vosatka, A. et al. Biochemistry 38, 12841– 12849 (1999).

  11. 11

    Hudson, J. D. et al. J. Exp. Med. 190, 1375– 1382 (1999).

  12. 12

    Mitchell, R. A. et al. J. Biol. Chem. 274, 18100– 18106 (1999).

  13. 13

    Chesney, J. et al. Mol. Med. 5, 181–191 (1999).

  14. 14

    Abe, R. et al. J. Immunol. (in the press).

  15. 15

    Calandra, T. et al. Nature Med. 6, 164– 170 (2000).

Download references

Author information

Correspondence to Richard Bucala.

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.