Sensations of pain have many causes, from tissue damage to sunburn. Several types of pain are sensed by a mechanism involving ATP — the chemical powerhouse of all cells.
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Cook, S., McCleskey, E. ATP, pain and a full bladder. Nature 407, 951–952 (2000). https://doi.org/10.1038/35039648
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DOI: https://doi.org/10.1038/35039648