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Circadian clockwork: two loops are better than one


The spectacularly successful race over the past three years to place our understanding of the circadian clockwork of mammals into a molecular framework is beginning to yield the cardinal example of the molecular-genetic control of behaviour. This perspective describes recent evidence for the conservation of a double-loop, autoregulatory feedback mechanism across the best understood eukaryotic circadian systems, and discusses how these findings may illuminate some long-standing puzzles concerning our subliminal sense of circadian time.

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Hastings, M. Circadian clockwork: two loops are better than one. Nat Rev Neurosci 1, 143–146 (2000).

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