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Hayflick, his limit, and cellular ageing

Nature Reviews Molecular Cell Biology volume 1, pages 7276 (2000) | Download Citation

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Abstract

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick limit’. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.

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  1. University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard , Dallas, Texas 75390-9039, USA.

    • Jerry W. Shay
    •  & Woodring E. Wright

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https://doi.org/10.1038/35036093

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