Regulated import and degradation of a cytosolic protein in the yeast vacuole

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Abstract

The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

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Chiang , H., Schekman, R. Regulated import and degradation of a cytosolic protein in the yeast vacuole. Nature 350, 313–318 (1991) doi:10.1038/350313a0

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