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Thrombin signalling and protease-activated receptors

Naturevolume 407pages258264 (2000) | Download Citation



How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

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I thank B. Black, H. Bourne, I. Charo, P.-T. Chuang, C. Esmon and the members of my laboratory for critical reading of the manuscript, and T. Schoop for illustrations.

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  1. Cardiovascular Research Institute and Departments of Medicine and Pharmacology, University of California at San Francisco, HSE-1300, 505 Parnassus Avenue, San Francisco, 94143-0130, California , USA

    • Shaun R. Coughlin


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Correspondence to Shaun R. Coughlin.

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