Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

Abstract

BRAIN-derived neurotrophic factor (BDNF), present in minute amounts in the adult central nervous system1, is a member of the nerve growth factor (NGF) (ref. 2) family, which includes neurotrophin-3 (NT-3) (refs 3–5). NGF, BDNF and NT-3 all support survival of subpopulations of neural crest-derived sensory neurons3–5; most sympathetic neurons are responsive to NGF (ref. 2), but not to BDNF1,6,7; NT-3 and BDNF, but not NGF (ref. 6), promote survival of sensory neurons of the nodose ganglion3–8. BDNF, but not NGF, supports the survival of cultured retinal ganglion cells9 but both NGF and BDNF promote the survival of septal cholinergic neurons in vitro10,11. However, knowledge of their precise physiological role in development and maintenance of the nervous system neurons is still limited. The BDNF gene is expressed in many regions of the adult CNS12‐14, including the striatum12. A protein partially purified from bovine striatum, a target of nigral dopaminergic neurons, with characteristics apparently similar to those of BDNF, can enhance the survival of dopaminergic neurons in mesencephalic cultures15. BDNF seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease. Here we report the effects of BDNF on the survival of dopaminergic neurons of the developing substantia nigra.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Barde, Y.-A., Edgar, D. & Thoenen, H. EMBO J 1, 549–553 (1982).

    CAS  Article  Google Scholar 

  2. 2

    Levi-Montalcini, R. & Angeletti, P. U. Physiol. Rev. 48, 534–569 (1968).

    CAS  Article  Google Scholar 

  3. 3

    Hohn, A., Leibrock, J., Bailey, K. & Barde, Y.-A. Nature 344, 339–341 (1990).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Maisonpierre, P. C. et al. Science 247, 1446–1451 (1990).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Rosenthal, A. et al. Neuron 4, 767–773 (1990).

    CAS  Article  Google Scholar 

  6. 6

    Lindsay, R. M., Thoenen, H. & Barde, Y.-A. Devl Biol. 112, 318–328 (1985).

    Google Scholar 

  7. 7

    Davies, A. M., Thoenen, H. & Barde, Y.-A. J. Neurosci. 6, 1897–1904 (1986).

    CAS  Article  Google Scholar 

  8. 8

    Hofer, M. M. & Barde, Y.-A. Nature 331, 261–262 (1988).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Johnson, J. E., Barde, Y.-A., Schwab, M. & Thoenen, H. J. Neurosci. 6, 3031–3038 (1986).

    CAS  Article  Google Scholar 

  10. 10

    Hartikka, J. & Hefti, F. J. Neurosci. 8, 2967–2985 (1988).

    CAS  Article  Google Scholar 

  11. 11

    Alderson, R. F., Alterman, A. L., Barde, Y.-A. & Lindsay, R. M. Neuron 5, 297–306 (1990).

    CAS  Article  Google Scholar 

  12. 12

    Hofer, M., Pagliusi, S. R., John, A., Leibrock, J. & Barde, Y.-A. EMBO J. 9, 2459–2464 (1990).

    CAS  Article  Google Scholar 

  13. 13

    Maisonpierre, P. C. et al. Neuron 5, 501–509 (1990).

    CAS  Article  Google Scholar 

  14. 14

    Phillips, H. S., Hains, J. M., Laramee, G. R., Rosenthal, A. & Winslow, J. W. Science 250, 290–294 (1990).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Dal Toso, R. et al. J. Neurosci. 8, 733–745 (1988).

    CAS  Article  Google Scholar 

  16. 16

    Bignami, A., Eng, L. F., Dahl, D. & Uyeda, C. T. Brain Res. 43, 429–435 (1972).

    CAS  Article  Google Scholar 

  17. 17

    Knusel, B., Michel, P. P., Schwaber, S. & Hefti, F. J. Neurosci. 10, 558–570 (1990).

    CAS  Article  Google Scholar 

  18. 18

    Rodriguez-Tébar, A., Dechant, G. & Barde, Y.-A. Neuron 4, 487–492 (1990).

    Article  Google Scholar 

  19. 19

    Chandler, C. E., Parson, L. M., Hosang, M. & Shooter, E. M. J. biol. Chem. 259, 6882–6889 (1984).

    CAS  Google Scholar 

  20. 20

    Zigmond, M. J. & Stricker, E. M. Int. Rev. Neurobiol. 31, 1–79 (1989).

    CAS  Article  Google Scholar 

  21. 21

    Sanchez-Ramos, J. R., Barrett, J. N., Goldstein, M., Weiner, W. & Hefti, F. Neurosci. Lett. 72, 215–220 (1986).

    CAS  Article  Google Scholar 

  22. 22

    Sanchez-Ramos, J., Michel, P., Weiner, W. J. & Hefti, F. J. Neurochem. 50, 1934–1944 (1988).

    CAS  Article  Google Scholar 

  23. 23

    Michel, P. P., Dandapani, B. K., Knusel, B., Sanchez-Ramos, J. & Hefti, F. J. Neurochem. 54, 1102–1109 (1990).

    CAS  Article  Google Scholar 

  24. 24

    Prochiantz, A., DiPorzio, U., Kato, A., Berger, B. & Glowinski, J. Proc. natn. Acad. Sci. U.S.A. 76, 5387–5391 (1979).

    ADS  CAS  Article  Google Scholar 

  25. 25

    DiPorzio, U., Daguet, M.-C., Glowinski, J. & Prochiantz, A. Nature 288, 370–373 (1980).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Prochiantz, A., Daguet, M.-C., Herbert, A. & Glowinski, J. Nature 293, 570–572 (1981).

    ADS  CAS  Article  Google Scholar 

  27. 27

    Denis-Donini, S., Glowinski, J. & Prochiantz, A. J. Neurosci. 3, 2292–2299 (1983).

    CAS  Article  Google Scholar 

  28. 28

    Ferrari, G., Minozzi, M. C., Toffano, G., Leon, A. & Skaper, S. D. Devl Biol. 133, 140–147 (1989).

    CAS  Article  Google Scholar 

  29. 29

    Otto, D. & Unsicker, K. J. Neurosci. 10, 1912–1921 (1990).

    CAS  Article  Google Scholar 

  30. 30

    Langston, J. W., Ballard, P., Tetrud, J. W. & Irwin, I. Science 219, 979–980 (1983).

    ADS  CAS  Article  Google Scholar 

  31. 31

    Langston, J. W., Forno, L. S., Rebert, C. S. & Irwin, I. Brain Res. 292, 390–394 (1984).

    CAS  Article  Google Scholar 

  32. 32

    Bottenstein, J. E. & Sato, G. H. Proc. natn. Acad. Sci. U.S.A. 76, 514–517 (1979).

    ADS  CAS  Article  Google Scholar 

  33. 33

    Wray, W., Boulikas, T., Wrax, V. P. & Hancock, R. Analyt. Biochem. 118, 197–203 (1981).

    CAS  Article  Google Scholar 

  34. 34

    Yancopoulos, G. D. et al. Cold Spring Harb. Symp. quant. Biol. (in the press).

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hyman, C., Hofer, M., Barde, YA. et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230–232 (1991). https://doi.org/10.1038/350230a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing