Abstract
Caffeine synthase is an enzyme that catalyses the final two steps in the caffeine biosynthesis pathway. We have cloned the gene encoding caffeine synthase from young leaves of tea (Camellia sinensis), opening up the possibility of creating tea and coffee (Coffea arabica) plants that are naturally deficient in caffeine. Consumers concerned about the possible adverse effects of caffeine consumption will welcome this development towards caffeine-free drinks that retain their flavour.
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Kato, M., Mizuno, K., Crozier, A. et al. Caffeine synthase gene from tea leaves . Nature 406, 956–957 (2000). https://doi.org/10.1038/35023072
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