Tissue invasion by leukaemic cells is stalled by loading them with a designer ribozyme.
Abstract
Chronic myelogenous leukaemia (CML) is a haematopoietic malignant disease associated with the expression of a chimaeric BCR–ABL gene1,2. We have designed an allosterically controllable ribozyme that specifically cleaves BCR–ABL messenger RNA and induces apoptosis in cultured CML cells3, and here we test it as a possible treatment of CML in a mouse model. We find that this ribozyme completely inhibits tumour-cell infiltration in these mice. To our knowledge, this is the first application of an artificial, allosterically controllable enzyme in animals, opening up the possibility of using ribozyme technology in the treatment of CML.
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Tanabe, T., Kuwabara, T., Warashina, M. et al. Oncogene inactivation in a mouse model. Nature 406, 473–474 (2000). https://doi.org/10.1038/35020190
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