Brief Communication | Published:

Signalling pathways

Kinase regulation in inflammatory response

Abstract

The transcription factor NF-κB is a pivotal regulator of innate immune responses, whose activity is rapidly induced by proinflammatory stimuli, most notably the tumour-necrosis factor TNFα and interleukin-1, viruses, and components of bacterial cell walls1. In addition, NF-κB protects cells from the induction of programmed cell death by pro-apoptotic stimuli such as TNFα (refs 2, 3). Another important anti-apoptotic signal-transducing protein is the protein kinase Akt (also known as protein kinase B), whose activity is strongly stimulated by growth factors4. Ozes et al.5 have suggested that Akt is involved in the TNFα-mediated activation of NF-κB5, implying that some of the anti-apoptotic activity of Akt may be mediated through NF-κB. However, we have failed to detect any involvement of Akt in the signalling pathway through which TNFα leads to NF-κB activation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Rothwarf, D. M. & Karin, M. The NF-κ B Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus http://www.stke.org/cgi/content/fullOC_sigtrans;1999/5/re1 (1999).

  2. 2

    Beg, A. A. & Baltimore, D. Science 274, 782–784 (1996).

  3. 3

    Liu, Z.-G, Hu, H., Goeddel, D. V. & Karin, M. Cell 87, 565–576 (1996).

  4. 4

    Hemmings, B. A. Science 275, 628–630 ( 1997).

  5. 5

    Ozes, O. N. et al. Nature 401, 82–85 (1999).

  6. 6

    Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.-F & Verma, I. M. Science 284, 321–325 (1999).

  7. 7

    Hu, Y. et al. Science 284, 316–320 (1999).

  8. 8

    Takeda, K. et al. Science 284, 313–316 (1999).

  9. 9

    Delhase, M., Hayakawa, M., Chen, Y. & Karin, M. Science 284, 309–313 (1999).

  10. 10

    Tojima, Y. et al. Nature 404, 778–782 (2000).

  11. 11

    Sizemore, N., Leung, S. & Stark, G. R. Mol. Cell. Biol. 19, 4798– 4805 (1999).

  12. 12

    Madrid, L. V. et al. Mol. Cell. Biol. 20, 1626– 1638 (2000).

Download references

Author information

Correspondence to Michael Karin.

Rights and permissions

Reprints and Permissions

About this article

Further reading

Figure 1: Akt is not involved in IKK activation.

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.