Statistical analyses of neuronal death rates in a variety of neurodegenerative disorders indicate that a 'one-hit' model of cell death may be common to all of them. In this model, affected neurons are in an abnormal state in which there is a higher chance that a rare catastrophic event will lead to cell death.
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Heintz, N. One-hit neuronal death. Nature 406, 137–139 (2000). https://doi.org/10.1038/35018196
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DOI: https://doi.org/10.1038/35018196
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