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A triclosan-resistant bacterial enzyme

An Erratum to this article was published on 24 August 2000


Triclosan is an antimicrobial agent that is widely used in a variety of consumer products and acts by inhibiting one of the highly conserved enzymes (enoyl-ACP reductase, or FabI) of bacterial fatty-acid biosynthesis. But several key pathogenic bacteria do not possess FabI, and here we describe a unique triclosan-resistant flavoprotein, FabK, that can also catalyse this reaction in Streptococcus pneumoniae. Our finding has implications for the development of FabI-specific inhibitors as antibacterial agents.

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Figure 1: FabK is an enoyl-ACP reductase.


  1. Rock, C. O. & Cronan, J. E. Jr Biochim. Biophys. Acta 1302, 1–16 (1996).

    Article  Google Scholar 

  2. Heath, R. J. & Rock, C. O. J. Biol. Chem. 270, 26538–26542 (1995).

    Article  CAS  Google Scholar 

  3. McMurray, L. M., Oethinger, M. & Levy, S. Nature 394, 531–532 (1998).

    Article  ADS  Google Scholar 

  4. Heath, R. J. et al. J. Biol. Chem. 273, 30316–30321 (1998).

    Article  CAS  Google Scholar 

  5. Heath, R. J. et al. J. Biol. Chem. 274, 11110–11114 (1999).

    Article  CAS  Google Scholar 

  6. Levy, C. W. et al. Nature 398, 383–384 (1999).

    Article  ADS  CAS  Google Scholar 

  7. Rozwarski, D., Grant, G., Barton, D., Jacobs, W. & Sacchettini, J. C. Science 279, 98–102 (1998).

    Article  ADS  CAS  Google Scholar 

  8. Nagy, M., Lacroute, F. & Thomas, D. Proc. Natl Acad. Sci. USA 89, 8966–8970 (1992).

    Article  ADS  CAS  Google Scholar 

  9. Schweizer, H. P. Antimicrob. Agents Chemother. 42, 394–398 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Hoang, T. T. & Schweizer, H. P. J. Bacteriol. 181, 5489–5497 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Heath, R. J. & Rock, C. O. J. Biol. Chem. 271, 1833–1836 (1996).

    Article  CAS  Google Scholar 

  12. Bhargava, H. N. & Leonard, P. A. Am. J. Infect. Control 24, 209–218 (1996).

    Article  CAS  Google Scholar 

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Correspondence to Charles O. Rock.

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Heath, R., Rock, C. A triclosan-resistant bacterial enzyme. Nature 406, 145–146 (2000).

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