The neurobiology of cognition

Article metrics

  • An Erratum to this article was published on 03 February 2000

Perhaps the deepest mysteries facing the natural sciences concern the higher functions of the central nervous system. Understanding how the brain gives rise to mental experiences looms as one of the central challenges for science in the new millennium.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1

Photograph by David G. Muir.

Figure 2: Localization of mental functions.

Imaging data assembled by C. J. Doane.

Figure 3: Illustration of the representational and microcircuit levels of analysis.

References

  1. 1

    Ogawa, S. et al. Proc. Natl Acad. Sci. USA 89, 5951– 5955 (1992).

  2. 2

    Posner, M. I. & Raichle, M. E. Proc. Natl Acad. Sci. USA 95, 763–764 (1998).

  3. 3

    Sell, L. A. et al. Eur. J. Neurosci. 11, 1042– 1048 (1999).

  4. 4

    Wandell, B. A. Annu. Rev. Neurosci. 22, 145–173 (1999).

  5. 5

    Hubel, D. H. Eye, Brain, and Vision (Scientific American Library, New York, 1995).

  6. 6

    Parker, A. J. & Newsome, W. T. Annu. Rev. Neurosci. 21, 227–277 (1998).

  7. 7

    Tanaka, K. Curr. Opin. Neurobiol. 2, 502–505 (1992).

  8. 8

    Fuster, J. M. Memory in the Cerebral Cortex (MIT Press, Cambridge, 1995).

  9. 9

    Goldman-Rakic, P. S. Proc. Natl Acad. Sci. USA 9, 13473– 13480 (1996).

  10. 10

    Desimone, R. & Duncan, J. Annu. Rev. Neurosci. 18, 193–222 (1995).

  11. 11

    Maunsell, J. H. Science 270, 764–769 ( 1995).

  12. 12

    Colby, C. L. & Goldberg, M. E. Annu. Rev. Neurosci. 22, 319–349 (1999).

  13. 13

    Salzman, C. D., Murasugi, C. M., Britten, K. H. & Newsome, W. T. J. Neurosci. 12, 2331–2355 (1992).

  14. 14

    Martinez et al. Nature Neurosci. 2, 364–369 (1999).

  15. 15

    George, J. S. et al. J. Clin. Neurophysiol. 12, 406– 431 (1995).

  16. 16

    Hubener, M., Shoham, D., Grinvald, A. & Bonhoeffer, T. J. Neurosci. 17, 9270–9284 ( 1997).

  17. 17

    Svoboda, K., Helmchen, F., Denk, W. & Tank, D. W. Nature Neurosci. 2, 65–73 (1999 ).

  18. 18

    Wang, S. S. & Augustine, G. J. Neuron 15, 755–760 (1995).

  19. 19

    Jackson, F. Phil. Quarterly 32, 127–136 (1982).

  20. 20

    Thompson, E. Phil. Studies 68, 321–349 (1992).

  21. 21

    Nagel, T. Phil. Rev. 4, 435–450 ( 1974).

  22. 22

    Shadlen, M. N. & Newsome, W. T. Proc. Natl Acad. Sci. USA 93, 628–633 (1996).

  23. 23

    Romo, R. & Salinas, E. Curr. Opin. Neurobiol. 9, 487–493 (1999).

  24. 24

    Schall, J. D. & Thompson, K. G. Annu. Rev. Neurosci. 22, 241–260 ( 1999).

  25. 25

    Gallistel, C. R. Cognition 50, 151–170 ( 1994).

  26. 26

    Schultz, W., Dayan, P. & Montague, P. R. Science 275, 1593– 1599 (1997).

  27. 27

    Schultz, W. J. Neurophysiol. 80, 1–27 (1998).

  28. 28

    Platt, M. L. & Glimcher, P. W. Nature 400, 233–238 (1999).

Download references

Acknowledgements

We thank M. Schnitzer for useful suggestions during the preparation of the manuscript.

Author information

Correspondence to William T. Newsome.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nichols, M., Newsome, W. The neurobiology of cognition. Nature 402, C35–C38 (1999) doi:10.1038/35011531

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.