Letter | Published:

An endogenous retrovirus mediating deletion of αβ T cells?

Abstract

A SPECIAL class of self-antigens (endogenous superantigens) is capable of deleting many murine T cells on the basis of their expression of particular T-cell receptor Vβ gene segments. In mice that endogenously express these antigens, tolerance is mediated in part by the clonal deletion of the relevant Vβ-bearing T cells1–17. The deletion of I–E-reactive Vβ 5.2-bearing T cells is dependent on the coexpression of an I–E tolerogenic coligand (Etc)14 and the gene for one of these coligands, Etc-1, maps to chromosome 12, near the mouse mammary tumour viral integrant, Mtv-9. Here we report a perfect genetic linkage between Etc-1 and Mtv-9 and show that Etc-1 is also involved in the I–E-dependent deletion of T cells bearing Vβ5.1 and Vβ11 domains. We also demonstrate that Mtv-9 transcripts are present in B cells expressing Etc-1 and suggest that the coligand recognized by roughly 15% of all T lymphocytes is encoded by the Mtv-9 genome.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bill, J., Kanagawa, O., Linten, J., Utsunomiya, Y. & Palmer, E. J. molec. cell. Immunol. 4, 269–280 (1990).

  2. 2

    Bill, J., Kanagawa, O., Woodland, D. & Palmer, E. J. exp. Med. 169, 1405–1419 (1989).

  3. 3

    Tomonari, K., & Lovering, E. Immunogenetics 28, 445 (1988).

  4. 4

    Okada, C. Y. & Weissman, I. L. J. exp. Med. 169, 1703–1719 (1989).

  5. 5

    Bill, J., Appel, V. B. & Palmer, E., Proc. natn. Acad. Sci. U.S.A. 85, 9184–9188 (1988).

  6. 6

    Kappler, J. W. et al. Cell 49, 263–272 (1987).

  7. 7

    Kappler, J., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

  8. 8

    Pullen, A. M., Marrack, P. & Kappler, J. W. Nature 335, 796–801 (1988).

  9. 9

    MacDonald, H. R. et al. Nature 332, 40–45 (1988).

  10. 10

    Kanagawa, O., Palmer, E. & Bill, J. Cell Immunol. 119, 412–426 (1989).

  11. 11

    Okada, C. Y., Holzmann, B., Guidos, C., Palmer, E. & Weissman, I. L. J. Immunol. 144, 3473–3477 (1990).

  12. 12

    Kappler, J., Staerz, U., White, J. & Marrack, P. Nature 332, 35–40 (1988).

  13. 13

    Happ, M. P., Woodland, D. L. & Palmer, E. Proc. natn. Acad. Sci. U.S.A. 86, 6293–6296 (1989).

  14. 14

    Woodland, D., Happ, M. P., Bill, J. & Palmer, E. Science 247, 964–967 (1990).

  15. 15

    Vacchio, M. S., Ryan, J. J. & Hodes, R. J. J. exp. Med. 172, 802–813 (1990).

  16. 16

    Tomonari, K. Immunol. Rev. 116, 139–157 (1990).

  17. 17

    Palmer, E., Woodland, D. L., Happ, M. P., Bill, J. & Kanagawa, O. Cold Spring Harb. Symp. quant. Biol. LIV, 135–145 (1989).

  18. 18

    Eicher, E. M. & Lee, B. K. Genetics 125, 431–446 (1990).

  19. 19

    Lee, B. K. & Eicher, E. M. J. Virol. 64, 4568–4572 (1990).

  20. 20

    Peters, G. et al. Virology 59, 535–544 (1986).

  21. 21

    Kozak, C. et al. J. Virol. 61, 1651–1654 (1987).

  22. 22

    Taylor, B. A. in Origin of Inbred Mice (ed. Morse, H. C.) 423–438 (Academic Press, New York, 1987).

  23. 23

    King, L. B. & Corley, R. B. Proc. natn. Acad. Sci. U.S.A. 86, 2814–2819 (1989).

  24. 24

    Sharma, S., King, L. B. & Corley, R. B. J. Immunol. 141, 2510–2518 (1988).

  25. 25

    King, L. B., Lund, F. E., White, D. A., Sharma, S. & Corley, R. B. J. Immunol. 144, 3218–3227 (1990).

  26. 26

    Ledbetter, J. A. & Herzenberg, L. A. Immunol. Rev. 47, 63–90 (1979).

  27. 27

    Dialynas, D. et al. J. Immunol. 131, 2445–2451 (1983).

  28. 28

    Kumagai, N., Benedict, S., Mills, G. & Gelfand, E. J. Immunol. 139, 1393–1399 (1987).

  29. 29

    Bill, J. et al. J. exp. Med. 169, 115–133 (1989).

  30. 30

    Pennell, C. A. et al. Proc. natn. Acad. Sci. U.S.A. 82, 3799–3803 (1985).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.