Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene therapeutics

The direct delivery of purified genes in vivo and their application as drugs, without the use of retroviruses, is discussed.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Felgner, P.L. Adv. Drug Deliv. Rev. 5, 163–187 (1990).

    Article  CAS  Google Scholar 

  2. Israel, M.A., Chan, H.W., Hourihan, S.L., Rowe, W.P. & Martin, M.A. J. Virol. 29, 990–996 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Bouchard, L., Gelinas, C., Asselin, C. & Bastin, M. Virol. 135, 53–64 (1984).

    Article  CAS  Google Scholar 

  4. Dubensky, T.W., Campbell, B.A. & Villarreal, L.P. Proc. natn. Acad. Sci. U.S.A. 81, 7529–7533 (1984).

    Article  ADS  CAS  Google Scholar 

  5. Fung, Y.K.T., Crittenden, L.B., Fadly, A.M. & Kung, H.J. Proc. natn. Acad. Sci. U.S.A. 80, 353–357 (1983).

    Article  ADS  CAS  Google Scholar 

  6. Seeger, C., Ganem, D. & Varmus, H.E. Proc. natn. Acad. Sci. U.S.A. 81, 5849–5852 (1984).

    Article  ADS  CAS  Google Scholar 

  7. Nicolau, C., LePape, A., Soriano, P., Gargette, F. & Juhel, M.F. Proc. natn. Acad. Sci. U.S.A. 80, 1068–1072 (1983).

    Article  ADS  CAS  Google Scholar 

  8. Benvenisty, N. & Reshef, L. Proc. natn. Acad. Sci. U.S.A. 83, 9551–9555 (1986).

    Article  ADS  CAS  Google Scholar 

  9. Wang, C.Y. & Huang, L. Proc. natn. Acad. Sci. U.S.A. 84, 7851–7855 (1987).

    Article  ADS  CAS  Google Scholar 

  10. Kaneda, Y., Iwai, K. & Uchida, T. Science 243, 375–378 (1989).

    Article  ADS  CAS  Google Scholar 

  11. Wu, G.Y. & Wu, C.H. J. biol. Chem. 263, 14621–14624 (1988).

    CAS  PubMed  Google Scholar 

  12. Wu, C., Wilson, J.M. & Wu, G.Y. J biol. Chem. 264, 16985–16987 (1989).

    CAS  PubMed  Google Scholar 

  13. Malone, R.W. Focus 11, 4–7 (1989).

    Google Scholar 

  14. Holt, C.E., Garlick, N. & Cornel, E. Neuron 4, 203–214 (1990).

    Article  CAS  Google Scholar 

  15. Ono, T., Funino, Y., Tomofusa, T. & Masaaki, T. Neurosci. Lett. 117, 259–263 (1990).

    Article  CAS  Google Scholar 

  16. Brigham, K.L., Meyrick, B., Christman, B., Magnuson, M., King, G. & Berry, L.C. Jr. Am J. med. Sci 298, 278–281 (1989).

    Article  CAS  Google Scholar 

  17. Nabel, E.G., Plautz, G. & Nabel, G. Science 249, 1285–1288 (1990).

    Article  ADS  CAS  Google Scholar 

  18. Wolff, J.A. et al. Science 247, 1465–1468 (1990).

    Article  ADS  CAS  Google Scholar 

  19. Lin, H., Parmacek, M.S., Morle, G., Bolling, S. & Leiden, J.M. Circulation 82, 2217–2221 (1990).

    Article  CAS  Google Scholar 

  20. Yang, N.S., Burkholder, J., Roberts, B., Marinell, B. & McCabe, D. Proc. natn. Acad. Sci. U.S.A. 87, 9568–9572 (1990).

    Article  ADS  CAS  Google Scholar 

  21. Johnston, S.A. Nature 346, 776–777 (1990).

    Article  ADS  CAS  Google Scholar 

  22. Germain, R.N. Nature 322, 687–689 (1986).

    Article  ADS  CAS  Google Scholar 

  23. Bevin, M.J. Nature 325, 192–194 (1987).

    Article  ADS  Google Scholar 

  24. Townsend, A. & Bodmer, H. Ann. Rev. Immunol. 7, 601–624 (1990).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Felgner, P., Rhodes, G. Gene therapeutics. Nature 349, 351–352 (1991). https://doi.org/10.1038/349351a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/349351a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing