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Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

Nature volume 349, pages 329–331 (1991)Cite this article

Abstract

IRRADIATED MHC-heterozygous mice often reject bone marrow cells transplanted from one of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to violate the laws of transplantation1,2. Rejection of parental and allogeneic marrow cells also differs from conventional T cell-mediated rejection mechanisms as it is effected by NK1.1+cells3–5. To account for the unusual specificity of bone marrow rejection, it has been proposed that NK1.1+ cells destroy marrow cells that fail to express the full complement of self MHC class I (MHC-I) molecules5. We show here that NK1.1+ cells in normal mice reject haemopoietic transplants from mice that are deficient for normal cell-surface MHC-I expression because of a targeted mutation in the β2-microglobulin gene6–9. These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection.

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Author notes

  1. Mark Bix, Nan-Shih Liao & David Raulet

    Present address: Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA

Authors and Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusets, 02139, USA

    Mark Bix, Nan-Shih Liao & David Raulet

  2. Whitehead Institute for Biomedical Research, Nine Cambridge Center,

    Maarten Zijlstra, Janet Loring & Rudolf Jaenisch

  3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA

    Janet Loring & Rudolf Jaenisch

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  1. Mark Bix
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  2. Nan-Shih Liao
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  5. Rudolf Jaenisch
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  6. David Raulet
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Bix, M., Liao, NS., Zijlstra, M. et al. Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 349, 329–331 (1991). https://doi.org/10.1038/349329a0

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