CCR5 is characteristic of Th1 lymphocytes

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Abstract

CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4.

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Figure 1: CCR5 is preferentially expressed in Th1 lymphocytes.
Figure 2: Expression of CCR5, CXCR3 and CCR3 in rheumatoid arthritis.

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