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Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster

Abstract

VARIATION in quantitative characters underlies much adaptive evolution and provides the basis for selective improvement of domestic species, yet the genetic nature of quantitative variation is poorly understood1. Many loci affecting quantitative traits have been identified by the segregation of mutant alleles with major qualitative effects2,3. These alleles may represent an extreme of a continuum of allelic effects, and most quantitative variation could result from the segregation of alleles with subtle effects at loci identified by alleles with major effects4–6. The achaete-scute complex in Drosophila melanogaster plays a central part in bristle development7,8 and has been characterized at the molecular level9,10. The hypothesis that naturally occurring quantitative variation in bristle number could be associated with wild-type alleles of achaete-scute was tested by correlating phenotypic variation in bristle number with molecular variation in restriction maps in this region among chromosomes extracted from natural populations. DNA insertion variation in the achaete-scute region was found to be strongly associated with variation in bristle number.

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References

  1. Falconer, D. S. Introduction to Quantitative Genetics (Longman, Harlow, 1989).

    Google Scholar 

  2. Lindsley, D. L. & Grell, E. H. Genetic Variations of Drosophila melanogaster (Carnegie Inst. Washington, 1968).

    Google Scholar 

  3. Mackay, T. F. C. in Evolution and Animal Breeding (eds Hill, W. G. & Mackay, T. F. C.) 113–119 (C.A.B. International, Wallingford, 1989).

    Google Scholar 

  4. Thompson, J. N. Jr Nature 258, 665–668 (1975).

    ADS  Article  Google Scholar 

  5. Robertson, D. S. J. theor. Biol. 117, 1–10 (1985).

    CAS  Article  Google Scholar 

  6. Mackay, T. F. C. Genetics 111, 351–374 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ghysen, A. & Dambly-Chaudière, C. Trends Genet. 5, 251–255 (1989).

    CAS  Article  Google Scholar 

  8. Ghysen, A. & Dambly-Chaudière, C. Genes Dev. 2, 495–501 (1988).

    CAS  Article  Google Scholar 

  9. Campuzano, S. et al. Cell 40, 327–338 (1985).

    CAS  Article  Google Scholar 

  10. Villares, R. & Cabrera, C. V. Cell 50, 415–424 (1987).

    CAS  Article  Google Scholar 

  11. Aguadė, M., Miyashita, N. & Langley, C. H. Genetics 122, 607–615 (1989).

    PubMed  PubMed Central  Google Scholar 

  12. Miyashita, N., Laurie-Ahlberg, C. C., Wilton, A. N. & Emigh, T. H. Genetics 113, 321–335 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Ruiz-Gómez, M. & Modolell, J. Genes Dev. 1, 1238–1246 (1987).

    Article  Google Scholar 

  14. Mackay, T. F. C. Genet. Res. 49, 225–233 (1987).

    Article  Google Scholar 

  15. Mackay, T. F. C. Genet. Res. 48, 77–87 (1986).

    Article  Google Scholar 

  16. Lai, C. & Mackay, T. F. C. Genetics 124, 627–636 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Robertson, A. in Heritage from Mendel (ed. Brink, A.) 265–280 (Univ. Wisconsin Press, Madison, 1967).

    Google Scholar 

  18. Shrimpton, A. E. & Robertson, A. Genetics 118, 445–459 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Hartley, D. & White, R. Trends Genet. 6, 199–201 (1990).

    CAS  Article  Google Scholar 

Download references

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Mackay, T., Langley, C. Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster. Nature 348, 64–66 (1990). https://doi.org/10.1038/348064a0

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