Abstract
Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.
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References
Townsend, A. & Bodmer, H. A. Rev. Immun. 7, 601–624 (1989).
Swain, S. L. Immunol. Rev. 74, 129–142 (1983).
Townsend, A., Ohlen, C., Bastin, J., Foster, L. & Karre, K. Nature 340, 443–448 (1989).
Unanue, E. R. & Alien, P. M. Science 236, 551–557 (1987).
Ziegler, K. & Unanue, E. R. Proc. natn. Acad. Sci. U.S.A. 78, 175–178 (1982).
Guagliardi, L. E. et al. Nature 343, 133–139 (1990).
Bjorkman, P. et al. Nature 329, 506–512 (1987).
Bjorkman, P. et al. Nature 329, 512–519 (1987).
Brown, J. H. et al. Nature 332, 845–850 (1988).
Charron, D. & Me Devitt, H. O. Proc. natn. Acad. Sci. U.S.A. 76, 6567–6571 (1979).
Kvist, S., Wiman, K., Claesson, L., Peterson, P. A., & Dobberstein, B. Cell 29, 61–69 (1982).
Machamer, C. E. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 81, 1287–1291 (1984).
Nguyen, Q. W. & Humphreys, R. E. J. biol. Chem. 264, 1631–1637 (1989).
Sung, E. & Jones, P. P. Molec. Immun. 18, 899–913 (1981).
Quaranta, V. et al. J. Immun. 132, 1990–1905 (1984).
Jones, P. P., Murphy, D. B., Hewgill, D. & McDevitt, H. O. Immunochemistry 16, 51–60 (1978).
Claesson-Welsh, L. & Peterson, P. A. J. Immun. 135, 3551–3557 (1985).
Sekaly, R. P., Tonnelle, C., Strubin, M., Mach, B. & Long, E. O. J. exp. Med. 164, 1490–1504 (1986).
Miller, J. & Germain, R. N. J. exp. Med. 164, 1478–1489 (1986).
Stockinger, B. et al. Cell 56, 683–689 (1989).
Peterson, M. & Miller, J. Nature 345, 172–174 (1990).
Buus, S., Sette, A. & Grey, H. M. Immunol. Rev. 98, 115–141 (1987).
Roche, P. A. & Cresswell, P. Nature 345, 615–618 (1990).
Lipp, J. & Dobberstein, B. Cell 46, 1103–1112 (1986).
Claesson, L., Larhammar, D., Rask, L. & Peterson, P. A. Proc. natn. Acad. Sci. U.S.A. 80, 7395–7399 (1983).
Kuroda, K., Hauser, C., Rott, R., Klenk, H. D. & Doerfler, W. EMBO J. 5, 1359–1365 (1986).
Carra, G. & Accolla, R. S. J. exp. Med. 165, 47–63 (1987).
Marks, M. S. & Cresswell, P. J. Immun. 136, 2519–2525 (1986).
Kaufman, J. F., Auffray, C., Korman, A. J., Shackelford, D. A. & Strominger, J. Cell. 36, 1–13 (1984).
Nilsson, T., Jackson, M. & Peterson, P. A. Cell 58, 707–718 (1989).
Thomas, L. J., Nguyen, Q. V., Elliott, W. L. & Humphreys, R. E. J. Immun. 140, 2670–2674 (1988).
Buerstedde, J. M. et al. J. exp. Med. 168, 823–837 (1988).
Kwok, W. W., Lotshaw, C., Milner, E. C. B., Knitter-Jack, N. & Nepom, G. T. Proc. natn. Acad. Sci. U.S.A. 86, 1027–1030 (1989).
Giles, R. C. et al. J. exp. Med. 157, 1461–1470 (1983).
O'Sullivan, D. et al. J. Immun. in the press.
Wraight, C. J. et al. J. biol. Chem. 265, 5787–5792 (1990).
Nowell, J. & Quaranta, V. J. exp. Med. 162, 1371–1376 (1985).
Blum, J. S. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 85, 3975–3979 (1988).
Nguyen, Q. V., Knapp, W. & Humphreys, R. E. Hum. Immun. 24, 153–163 (1989).
Svejgaard, A., Platz, P. & Ryder, L. P. Immunol. Rev. 70, 193–218 (1983).
Todd, J. A., Bell, J. I. & McDevitt, H. O. Nature 329, 599–604 (1987).
Towbin, H., Staehelin, T. & Gordan, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350–4354 (1979).
Greenwood, F. C., Hunter, W. M. & Glover, J. S. Biochem. J. 89, 114–123 (1963).
Scatchard, G. Ann. N. Y. Acad. Sci. 51, 660–672 (1949).
McElligott, D. L. ., Sorger, S. B., Matis, L. A. & Hedrick, S. M. J. Immun. 140, 4123–4131 (1988).
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Teyton, L., O'Sullivan, D., Dickson, P. et al. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways. Nature 348, 39–44 (1990). https://doi.org/10.1038/348039a0
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DOI: https://doi.org/10.1038/348039a0
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