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Alzheimer's disease

A technical KO of amyloid-β peptide

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Figure 1: The influence of presenilin-1 (PS1) on proteolytic processing of the amyloid precursor protein (APP).
Figure 2: Model for the two-site cleavage of the sterol regulatory element binding protein (SREBP).


  1. De Strooper, al. Nature 391, 387–390 (1998).

    Article  ADS  CAS  Google Scholar 

  2. Haass, C. Neuron 18, 687–690 (1997).

    Google Scholar 

  3. Selkoe, D. J. J. Biol. Chem. 271, 18295–18298 (1996).

    Google Scholar 

  4. Capell, A. et al. (in the press).

  5. Wong, P. al. Nature 387, 288–292 (1997).

    Article  ADS  CAS  Google Scholar 

  6. Shen, al. Cell 89, 629–639 (1997).

    Google Scholar 

  7. De Strooper, al. EMBO J. 14, 4932–4938 (1995).

    Google Scholar 

  8. Brown, M. S. & Goldstein, J. L. Cell 89, 331–340 (1997).

    Google Scholar 

  9. Hartmann, al. Nature Med. 3, 1016–1020 (1997).

    Google Scholar 

  10. Cook, D. al. Nature Med. 3, 1021–1023 (1997).

    Google Scholar 

  11. Wild-Bode, al. J. Biol. Chem. 272, 16085–16088 (1997).

    Google Scholar 

Download references

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Haass, C., Selkoe, D. A technical KO of amyloid-β peptide. Nature 391, 339–340 (1998).

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