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Stimulation of p21ras upon T-cell activation


External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

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Downward, J., Graves, J., Warne, P. et al. Stimulation of p21ras upon T-cell activation. Nature 346, 719–723 (1990).

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