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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Nature volume 346, pages 629–633 (1990)Cite this article

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

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Authors and Affiliations

  1. Institute of Pathology, University Hospital, 8091, Zurich, Switzerland

    Hanspeter Pircher, Demetrius Moskophidis, Urs Rohrer, Hans Hengartner & Rolf M. Zinkernagel

  2. Preclinical Research, Sandoz Pharma Ltd., 4002, Basel, Switzerland

    Kurt Bürki

Authors
  1. Hanspeter Pircher
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  2. Demetrius Moskophidis
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  3. Urs Rohrer
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  4. Kurt Bürki
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  5. Hans Hengartner
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  6. Rolf M. Zinkernagel
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Pircher, H., Moskophidis, D., Rohrer, U. et al. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 346, 629–633 (1990). https://doi.org/10.1038/346629a0

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