Antibody-directed drug discovery

Article metrics

Abstract

By harnessing the remarkable power of the immune system to access the three-dimensional chemical information sequestered in target sites for drug ligands, antibody-directed drug discovery speeds the design of new therapeutic entities.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Burger, A. in Burger's Medicinal Chemistry 4th Edn, Pt 1. (Ed. Wolff, M.E.) 1–54 (Wiley, New York, 1980).

  2. 2

    DesJarlais, R.L., Sheridan, R.P., Seibel, G.L., Dixon, J.S. & Kuntz, I.D. J. med. Chem. 31, 722–729 (1988).

  3. 3

    Walsh, C.T. Trends biochem. Sci. 8, 254–257 (1983).

  4. 4

    Anti-idiotypes, Receptors, and Molecular Mimicry (Eds Linthicum, D.S. & Farid, N.R.) 1–154, 255–284 (Springer, New York, 1988).

  5. 5

    McPherson, A. in The Preparation and Analysis of Protein Crystals (Wiley, New York, 1982).

  6. 6

    Sheriff, S. et al. Proc. natn. Acad. Sci. U.S.A. 84, 8075–8079 (1987).

  7. 7

    Geysen, H.M., Rodda, S.J., Mason, T.J., Tribbik, G. & Schoofs, P.G. J. immunol. Meth. 102, 259–274 (1987).

  8. 8

    Williams, W.V. et al. Proc. natn. Acad. Sci. U.S.A 85, 6488–6492 (1988).

  9. 9

    Goodman, M. Bioponymers 24, 137–155 (1987).

  10. 10

    Kuntz, I.D. Protein Eng. (England) 1, 147–148 (1987).

  11. 11

    Cohen, F.E., Gregoret, L., Presnell, S.R. & Kuntz, I.D. Prog. clin. biol. Res. 289, 75–85 (1989).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wolff, M., McPherson, A. Antibody-directed drug discovery. Nature 345, 365–366 (1990) doi:10.1038/345365a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.