Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Product Review
  • Published:

Antibody-directed drug discovery

Nature volume 345, pages 365–366 (1990)Cite this article

Abstract

By harnessing the remarkable power of the immune system to access the three-dimensional chemical information sequestered in target sites for drug ligands, antibody-directed drug discovery speeds the design of new therapeutic entities.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Burger, A. in Burger's Medicinal Chemistry 4th Edn, Pt 1. (Ed. Wolff, M.E.) 1–54 (Wiley, New York, 1980).

    Google Scholar 

  2. DesJarlais, R.L., Sheridan, R.P., Seibel, G.L., Dixon, J.S. & Kuntz, I.D. J. med. Chem. 31, 722–729 (1988).

    Article  CAS  Google Scholar 

  3. Walsh, C.T. Trends biochem. Sci. 8, 254–257 (1983).

    Article  CAS  Google Scholar 

  4. Anti-idiotypes, Receptors, and Molecular Mimicry (Eds Linthicum, D.S. & Farid, N.R.) 1–154, 255–284 (Springer, New York, 1988).

  5. McPherson, A. in The Preparation and Analysis of Protein Crystals (Wiley, New York, 1982).

    Google Scholar 

  6. Sheriff, S. et al. Proc. natn. Acad. Sci. U.S.A. 84, 8075–8079 (1987).

    Article  ADS  CAS  Google Scholar 

  7. Geysen, H.M., Rodda, S.J., Mason, T.J., Tribbik, G. & Schoofs, P.G. J. immunol. Meth. 102, 259–274 (1987).

    Article  CAS  Google Scholar 

  8. Williams, W.V. et al. Proc. natn. Acad. Sci. U.S.A 85, 6488–6492 (1988).

    Article  ADS  CAS  Google Scholar 

  9. Goodman, M. Bioponymers 24, 137–155 (1987).

    Article  Google Scholar 

  10. Kuntz, I.D. Protein Eng. (England) 1, 147–148 (1987).

    Article  CAS  Google Scholar 

  11. Cohen, F.E., Gregoret, L., Presnell, S.R. & Kuntz, I.D. Prog. clin. biol. Res. 289, 75–85 (1989).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vice President for Research and Development, ImmunoPhar-maceutics, Inc., 11011 Via Frontera, San Diego, California, 92127, USA

    M. E. Wolff

  2. Professor and Chairman of the Department of Biochemistry, University of California, Riverside, USA

    A. McPherson

Authors
  1. M. E. Wolff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. McPherson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wolff, M., McPherson, A. Antibody-directed drug discovery. Nature 345, 365–366 (1990). https://doi.org/10.1038/345365a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/345365a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing