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Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

Nature volume 345, pages 344–346 (1990)Cite this article

Abstract

THE identification of activated ? cells in the brain of individuals with multiple sclerosis (MS) indicates that these cells are critical in the pathogenesis of this disease. In an attempt to elucidate the nature of the lymphocytic infiltration, we used the polymerase chain reaction to amplify T-cell antigen receptor (TCR) Vα sequences from transcripts derived from MS brain lesions. In each of three MS brains, only two to four rearranged TCR Vα transcripts were detected. No Vα transcripts could be found in control brains. Sequence analysis of transcripts encoded by the Vα 12.1 region showed rearrangements to a limited number of Jα region segments. These results imply that TCR Vα gene expression in MS brain lesions is restricted.

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Affiliations

  1. Department of Neurology, Stanford University, Stanford, California, 94305, USA

    Jorge R. Oksenberg, Robert B. Bell & Lawrence Steinman

  2. Department of Genetics and Pediatrics, Stanford University, Stanford, California, 94305, USA

    Lawrence Steinman

  3. Neuroimmunology Laboratory, LaTrobe University, Victoria, 3083, Australia

    Simon Stuart & Claude C. A. Bernard

  4. Department of Human Genetics, Cetus Corporation, Emeryville, California, 94608, USA

    Ann B. Begovich & Henry A. Erlich

Authors
  1. Jorge R. Oksenberg
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  2. Simon Stuart
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  3. Ann B. Begovich
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  4. Robert B. Bell
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  5. Henry A. Erlich
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  6. Lawrence Steinman
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  7. Claude C. A. Bernard
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Oksenberg, J., Stuart, S., Begovich, A. et al. Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients. Nature 345, 344–346 (1990). https://doi.org/10.1038/345344a0

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  • DOI: https://doi.org/10.1038/345344a0

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