Seed sows further doubts on cloning

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Plans by a Chicago embryologist to clone a human being have renewed pressure for swift action to ban the practice in the United States. But scientists warn that an ill-drafted law could stifle genuine research.

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Out of step: Seed faces opprobrium from the scientific community as well as legal hurdles. Credit: AP/CHARLES BENNETT

The provocative pronunciations of Richard Seed of Chicago, a Harvard-trained physicist who last week announced plans to clone a human being, appear to bear little relationship to reality. Seed has little money, few if any fertility physicians willing to help him, and no laboratory.

Furthermore, prohibitive scientific obstacles remain to such a feat. It took the Scottish scientist Ian Wilmut and his team 277 attempts to produce Dolly, the clone of an adult ewe (see Nature 385, 810;1997), and nothing suggests that the effort in humans is going to prove any easier.

“This has been played on front pages as though there's something to announce,” says Alexander Morgan Capron, a professor of law and medicine at the University of Southern California who is a member of the National Bioethics Advisory Commission (NBAC). “My own sense is that it belongs in the entertainment section.”

But, however dubious its origins, the tempest set off by Seed's announcement points to the fact that, at least in the United States, cloning a human being using private funds would break no law.

That could soon change. Seed “will not do human cloning in this country,” declared Donna Shalala, Secretary of Health and Human Services, on CBS television last Sunday (11 January). And President Bill Clinton, in his weekly radio address last Saturday, called Seed's announcement “profoundly troubling” and urged Congress to enact legislation when it reconvenes this month. “There is virtually unanimous consensus in the scientific and medical communities that attempting to use these cloning techniques to clone a human is untested and unsafe and morally unacceptable,” Clinton said.

He added that Seed's plans make it “clearer than ever” that cloning legislation he sent to the Congress last June is “exactly what is needed” (see Nature 387, 644; 1997). Clinton's Cloning Prohibition Act would ban for at least five years the cloning of human beings in the public and private sectors.

So far Congress has not acted on it. But the mood of legislators appears to be rapidly changing. Speaking on US television last Sunday, the House of Representatives majority leader, Richard Armey, declared Seed's project a “nasty business”. Referring to a House bill already introduced by congressman Vern Ehlers (Republican, Michigan), Armey said: “We are going to move that ban.” And Senator Bill Frist (Republican, Tennessee), the cardiac surgeon who chairs the Senate subcommittee that has jurisdiction on the issue, told Nature through a spokeswoman that he is considering introducing legislation to this end. “If Richard Seed gets credit for anything, it's for putting this issue back before Congress,” says Capron.

The lack of action in Congress has occurred despite a flurry of hearings that followed the announcement last February of Dolly's birth, the recommendation last June by NBAC that Congress should outlaw human cloning for a period (see Nature 387 217; 1997), and the submission to Congress of Clinton's bill, which in essence codifies the commission's recommendation.

Three bills authored by congressmen have also languished — two of them would bar federal funding for research on cloning humans and one would impose civil fines on anyone who produces a human clone (see Nature 386 97;1997).

Before Seed's announcement, Frist had been reluctant to legislate. The chairman of the public health subcommittee of the Senate Labor and Human Resources Committee said in October that “there is no reason for Congress to legislate” and that the issue ought instead to be debated in a “national dialogue”.

According to Margaret Camp, a spokeswoman for Frist, the senator thought until last week that a voluntary private sector moratorium on cloning called for by Clinton in March was being followed. That, combined with a ban on federal funding for human cloning imposed by Clinton at the same time, was considered by the senator to be sufficient. But, says Camp, Frist is now reconsidering his position in the light of Seed's announcement. “He is looking at legislation now. But it's with human cloning [for reproductive purposes]. He feels strongly about protecting research.”

Behind the congressional inaction on cloning over the last ten months has been not only a busy schedule in which the issue got pushed aside, but also abortion politics, as exemplified in the fate of the Clinton bill (see Nature 387, 748; 1997).

Despite courting Republicans and Democrats in the House and Senate, and support for the bill's approach from groups such as the Biotechnology Industry Organization, the White House has been unable to find a sponsor for the bill. This is partly because the bill — like the recommendations of the NBAC — does not prohibit use of cloning techniques in human embryo research.

Even Connie Morella, the liberal Republican congresswoman who represents the Maryland constituency that includes the National Institutes of Health, has not stepped forward to sponsor the legislation — although the White House courted her. Morella called last week for a bill to ban human cloning.

“Nobody in Congress wanted to touch [the Clinton bill] with a ten-foot pole,” says Roger Pedersen, a mammalian embryologist at the University of California, San Francisco, who speaks for the Federation of American Societies for Experimental Biology (FASEB). The federation, which represents 52,000 scientists, is pushing a different approach. In September, following the lead of the Society for Developmental Biology, it adopted a voluntary moratorium on cloning.

Since then, the American Society for Reproductive Medicine, representing 9,000 fertility physicians, and the Society for the Study of Reproduction, with 2,400 members, have adopted the same moratorium. Pedersen says the opprobrium heaped on Seed by fellow scientists last week is evidence of the power of peer pressure in the face of aberrant behaviour. “There's a circling of the wagons, with him outside,” he says.

Although FASEB does not condone human cloning at this stage, he adds, “Congress has been acting responsibly by not rushing legislation. Hastily written law can do more harm than good by deterring potentially beneficial research. That's why I think a voluntary moratorium is more effective.”

But Capron of the NBAC says that congressional inaction has resulted in domestic and international US failures. Domestically, he says, it has allowed a “cowboy” like Seed to pursue his ends unchallenged. And internationally, the fact that the United States has not condemned human cloning officially by passing the Clinton legislation “means that we're not in a leadership position”.

The Clinton legislation would ban the use of cloning to create children by anyone in the private or public sector. It would expire after five years, before which time the NBAC would be required to review developments and recommend whether the law should be extended. It includes explicit protections for cloning's research applications in DNA, cells, tissues and animals, but does not mention human embryo research. Embryo research — whether or not using cloning technology — is at present legal if financed privately, but barred from federal funding.

Scientific groups have said that they fear that, unlike the Clinton bill, those introduced by congressmen are so broadly worded and imprecise that they threaten research. A Senate bill introduced last February by Christopher Bond (Republican, Missouri) would bar the use of federal funds for “research with respect to the cloning of a human individual”. Bond said last week that he would push for a broader “emergency ban” to encompass the private sector.

Two House bills were introduced last winter by Vern Ehlers. One banned federal funding for “research that involves the use of a human somatic cell for the process of producing a human clone”. The other imposed a penalty of up to $5,000 on anyone “producing a human clone”. Ehlers later expanded the first bill to include a ban on use of cloning in human embryo research. The House Science Committee approved it last July; it had to be rewritten to win enough votes to be passed by the committee.

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