Abstract
INTERACTION with antigen-presenting accessory cells is thought to be an important step in B-cell activation1–5, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response6. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.
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Stamenkovic, I., Seed, B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 345, 74–77 (1990). https://doi.org/10.1038/345074a0
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DOI: https://doi.org/10.1038/345074a0
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