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G0 is a major growth cone protein subject to regulation by GAP-43

Nature volume 344, pages 836–841 (1990)Cite this article

Abstract

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-γ-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0in the growth cone may be regulated by intracellular as well as extracellular signals.

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Author notes

  1. Mark C. Fishman: To whom correspondence should be addressed.

Authors and Affiliations

  1. Developmental Biology Laboratory, Massachusetts General Hospital,

    Stephen M. Strittmatter, Dario Valenzuela & Mark C. Fishman

  2. Departments of Neurology and Medicine, Harvard Medical School,

    Stephen M. Strittmatter, Dario Valenzuela & Mark C. Fishman

  3. Howard Hughes Medical Institute, Boston, Massachusetts, 02114, USA

    Stephen M. Strittmatter, Dario Valenzuela & Mark C. Fishman

  4. Center for Neurobiology and Behavior, Columbia University, 722 W. 168th Street, New York, New York, 10032, USA

    Timothy E. Kennedy

  5. Cardiovascular Division, Brigham and Woman's Hospital, 75 Francis Street, Boston, Massachusetts, 02115, USA

    Eva J. Neer

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Strittmatter, S., Valenzuela, D., Kennedy, T. et al. G0 is a major growth cone protein subject to regulation by GAP-43. Nature 344, 836–841 (1990). https://doi.org/10.1038/344836a0

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