Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Nature volume 343, pages 536–540 (1990)Cite this article

Abstract

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hall, J. C. & Rosbash, M. BioEssays 7, 108–112 (1987).

    Article  CAS  Google Scholar 

  2. Siwicki, K. K., Eastman, C., Petersen, G., Rosbash, M. & Hall, J. C. Neuron 1, 141–150 (1988).

    Article  CAS  Google Scholar 

  3. Zerr, D. M. et al. (submitted).

  4. Konopka, R. J. & Benzer, S. Proc. natn. Acad Sci. U.S.A. 68, 2112–2116 (1971).

    Article  CAS  ADS  Google Scholar 

  5. Hall, J. C. & Rosbash, M. A. Rev. Neurosci. 11, 373–393 (1988).

    Article  CAS  Google Scholar 

  6. Liu, X., Lorenz, L., Yu, Q., Hall, J. C. & Rosbash, M. Genes Dev. 2, 228–238 (1988).

    Article  CAS  Google Scholar 

  7. Saez, L. & Young, M. W. Molec. cell. Biol. 8, 5378–5385 (1988).

    Article  CAS  Google Scholar 

  8. Konopka, R. J., Wells, S. & Lee, T. Molec. gen. Genet. 190, 284–288 (1983).

    Article  Google Scholar 

  9. Citri, Y. et al. Nature 326, 42–47 (1987).

    Article  CAS  ADS  Google Scholar 

  10. Yu, Q. et al. Proc. natn. Acad. Sci. U.S.A. 84, 784–788 (1987).

    Article  CAS  ADS  Google Scholar 

  11. Baylies, M. K., Bargiello, T. A., Jackson, F. R. & Young, M. W. Nature 326, 390–392 (1987).

    Article  CAS  ADS  Google Scholar 

  12. Smith, R. F. & Konopka, R. J. Molec. gen. Genet. 183, 243–251 (1981).

    Article  CAS  Google Scholar 

  13. Hamblen, M. et al. J. Neurogenet. 3, 249–291 (1986).

    Article  CAS  Google Scholar 

  14. Dowse, H. B. & Ringo, J. M. J. biol. Rhythms 2, 65–76 (1987).

    Article  CAS  Google Scholar 

  15. Hamblen-Coyle, M. et al. J. Neurogenet. 5, 229–256 (1989).

    Article  CAS  Google Scholar 

  16. Dushay, M. S., Rosbash, M. & Hall, J. C. J. biol. Rhythms 4, 1–27 (1989).

    Article  CAS  Google Scholar 

  17. Petersen, G., Hall, J. C. & Rosbash, M. EMBO J. 7, 3939–3947 (1988).

    Article  CAS  Google Scholar 

  18. Zehring, W. A. et al. Cell 39, 369–376 (1984).

    Article  CAS  Google Scholar 

  19. Bargiello, T. A., Jackson, F. R. & Young, M. W. Nature 312, 752–754 (1984).

    Article  CAS  ADS  Google Scholar 

  20. Reddy, P. et al. Cell 38, 701–710 (1984).

    Article  CAS  Google Scholar 

  21. Young, M. W., Jackson, F. R., Shin, H.-S. & Bargiello, T. A. Cold Spring Harb. Symp. quant. Biol. 50, 865–875 (1985).

    Article  CAS  Google Scholar 

  22. Lorenz, L. J., Hall, J. C. & Rosbash, M. Development 107, 869–880 (1989).

    CAS  PubMed  Google Scholar 

  23. Uhl, G. R. & Reppert, S. M. Science 232, 390–393 (1986).

    Article  CAS  ADS  Google Scholar 

  24. Brann, M. R. & Cohen, L. V. Science 236, 585–587 (1987).

    Article  ADS  Google Scholar 

  25. Loros, J. J., Denome, S. A. & Dunlap, J. C. Science 243, 385–388 (1989).

    Article  CAS  ADS  Google Scholar 

  26. Guiliano, G., Hoffman, N. E., Ko, K., Scolnik, P. A. & Cashmore, A. R. EMBO J. 7, 3635–3642 (1988).

    Article  Google Scholar 

  27. Kloppstech, K. Planta 165, 502–506 (1985).

    Article  CAS  Google Scholar 

  28. Nagy, F., Kay, S. A. & Chua, N.-H. Genes Dev. 2, 376–382 (1988).

    Article  CAS  Google Scholar 

  29. Piechulla, B. & Gruissem, W. EMBO J. 6, 3593–3599 (1987).

    Article  CAS  Google Scholar 

  30. Spiller, S. C., Kaufman, L. S., Thompson, W. F. & Briggs, W. R. Pl. Physiol. 84, 409–414 (1987).

    Article  CAS  Google Scholar 

  31. Taylor, W. C. Pl. Cell 1, 259–264 (1989).

    Article  CAS  Google Scholar 

  32. Oliver, D. B. & Phillips, J. P. Drosoph. Inf. Serv. 45, 58 (1970).

    Google Scholar 

  33. O'Connell, P. & Rosbash, M. Nucleic Acids Res. 12, 5495–5513 (1984).

    Article  CAS  Google Scholar 

  34. Smith, R. F. & Konopka, R. J. Molec. gen. Genet. 185, 30–36 (1982).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts, 02254, USA

    Paul E. Hardin & Michael Rosbash

  2. Department of Biology, Brandeis University, Waltham, Massachusetts, 02254, USA

    Paul E. Hardin, Jeffrey C. Hall & Michael Rosbash

Authors
  1. Paul E. Hardin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jeffrey C. Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael Rosbash
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hardin, P., Hall, J. & Rosbash, M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536–540 (1990). https://doi.org/10.1038/343536a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/343536a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing