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Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

Nature volume 343, pages 531–535 (1990)Cite this article

Abstract

The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an a-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.

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Author information

Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Tatsuhiko Kodama, Mason Freeman, Lucia Rohrer, Paul Matsudaira & Monty Krieger

  2. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA

    Mason Freeman

  3. Integrated Genetics/Genzyme, Framingham, Massachusetts, 01701, USA

    James Zabrecky

  4. Whitehead Institute for Biomedical Science, Cambridge, Massachusetts, 02142, USA

    Paul Matsudaira

Authors
  1. Tatsuhiko Kodama
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  2. Mason Freeman
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  3. Lucia Rohrer
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  4. James Zabrecky
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  5. Paul Matsudaira
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  6. Monty Krieger
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Kodama, T., Freeman, M., Rohrer, L. et al. Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. Nature 343, 531–535 (1990). https://doi.org/10.1038/343531a0

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  • DOI: https://doi.org/10.1038/343531a0

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