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Solid-phase protein sequence analysis

Nature volume 343, pages 291–292 (1990)Cite this article

The solutions to many protein analytical problems require flexible chemistries at a high sensitivity. Solid-phase sequence analysis is one way to eliminate limitations inherent in current methods.

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References

  1. Hewick, R.M., Hunkapiller, M.W., Hood, L.E. & Dreyer, W.J. J. biol. Chem. 256, 7990–7997 (1981).

    CAS  PubMed  Google Scholar 

  2. Laursen, R.A. Eur. J. Biochem. 20, 89–102 (1971).

    Article  CAS  PubMed  Google Scholar 

  3. Aebersold, R., Pipes, G., Nika, H., Hood, L.E. & Kent, S. B. H. Biochemistry 27, 6860–6867 (1988).

    Article  CAS  PubMed  Google Scholar 

  4. Aebersold, R. et al. in Methods in Protein Sequence Analysis (ed. Wittmann-Liebold, B.) (Springer, Berlin, 1989).

    Google Scholar 

  5. Pappin, D.J.C., Coull, J.M. & Koester, H. in Current Research in Protein Chemistry, 191–202 (ed. Villafranca, J.) (Academic, San Diego, in the press).

  6. Coull, J.M., Pappin, D.J.C., Mark, J., Aebersold, R. & Koester, H. Analyt. Biochem. Submitted.

  7. Third Symp. Protein Soc., Seattle, 29 July-2 August 1989. Manual prepared for MilliGen/Biosearch Protein Sequencing Forum.

  8. Solid-phase Methods in Protein Sequence Analysis (ed. Laursen, R.A.) (Pierce Chem. Co., Rockford, II, 1975).

  9. Wachter, E., Machleidt, W., Hofner, H. & Otto, J. FEBS Lett. 35, 97–102 (1973).

    Article  CAS  PubMed  Google Scholar 

  10. Aebersold, R., Teplow, D., Hood, L.E. & Kent, S.B.H. J. biol. Chem. 261, 4229–4238 (1986).

    CAS  PubMed  Google Scholar 

  11. Nika, H., Aebersold, R., Hood, L.E. & Kent, S.B.H. In preparation.

  12. Wettenhall, R.E.M., Aebersold, R., Hood, L.E. & Kent, S.B.H. Meth. Enzym. Submitted.

  13. Chang, J.Y. & Creaser, E.H. Biochem. J. 157, 77–82 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Yu, M. & Dovichi, N.J. Analyt. Chem. 61, 37–40 (1989).

    Article  Google Scholar 

  15. Jin, S.W., Chen, G.X., Palacz, Z. & Wittmann-Liebold, B. FEBS Lett. 198, 150–158 (1986).

    Article  CAS  PubMed  Google Scholar 

  16. Cheng, Y.F. & Dovichi, N.J. Science 242, 562–564 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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  1. Assistant Professor, Biochemistry, at the Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1W5

    Ruedi Aebersold

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  1. Ruedi Aebersold
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Aebersold, R. Solid-phase protein sequence analysis. Nature 343, 291–292 (1990). https://doi.org/10.1038/343291a0

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  • DOI: https://doi.org/10.1038/343291a0

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