Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

Abstract

THE survival, differentiation, proliferation and development of haemopoietic precursor cells and the functional activity of mature blood cells are all influenced by colony stimulating factors (CSFs)1. As haemopoietic cells rapidly die in the absence of appropriate CSF2,3, the promotion of cell survival mediated by CSFs, or growth factors, is fundamental to all the other effects exerted by these factors. This enhancement of cell survival is distinct from the stimulation of proliferation1,4. Here we show that the death of haemopoietic precursor cells on withdrawal of the relevant CSF is due to active cell death5,6, or apoptosis, indicating that CSFs promote cell survival by suppression of the process of apoptosis. The existence of a positive control mechanism regulating precursor cell survival has important implications both for the regulation of normal haemopoiesis and for tumorigenesis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Metcalf, D. Nature 335, 27–30 (1989).

    Article  ADS  Google Scholar 

  2. Paran, M. & Sachs, L. J. Cell. Physiol. 72, 247–249 (1969).

    Article  Google Scholar 

  3. Metcalf, D. J. cell. Physiol. 76, 89–100 (1970).

    Article  CAS  Google Scholar 

  4. Vaux, D. L., Cory, S. & Adams, J. M. Nature 335, 440–442 (1988).

    Article  CAS  ADS  Google Scholar 

  5. Kerr, J. F. R., Wyllie, A. H. & Currie, A. R. Br. J. Cancer 26, 239–257 (1972).

    Article  CAS  Google Scholar 

  6. Wyllie, A. H., Kerr, J. F. R. & Currie, A. R. Int. Rev. Cytol. 68, 251–305 (1981).

    Article  Google Scholar 

  7. Pratt, R. B. & Greene, R. M. Devel. Biol. 54, 135–145 (1976).

    Article  CAS  Google Scholar 

  8. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. & Owen, J. J. T. Nature 337, 181–184 (1989).

    Article  CAS  ADS  Google Scholar 

  9. Shi, Y., Sahai, B. M. & Green, D. R. Nature 339, 625–626 (1989).

    Article  CAS  ADS  Google Scholar 

  10. Duke, R. O. & Cohen, J. J. Lymphokine Res. 5, 289–299 (1986).

    CAS  PubMed  Google Scholar 

  11. Russel, J. K., Masokowski, V. R. & Dobos, C. B. J. Immunol. 124, 1100–1105 (1980).

    Google Scholar 

  12. Ucker, D. S. Nature 327, 62–64 (1987).

    Article  CAS  ADS  Google Scholar 

  13. Dexter, T. M., Garland, J., Scott, D., Scolnick, E. & Metcalf, D. J. exp. Med. 152, 1036–1047 (1980).

    Article  CAS  Google Scholar 

  14. Spooncer, E., Heyworth, C. M., Dunn, A. & Dexter, T. M. Differentiation 31, 111–118 (1986).

    Article  CAS  Google Scholar 

  15. Spooncer, E. et al. Curr. Top. micro. Immunol. 149, 109–116 (1989).

    CAS  Google Scholar 

  16. Whetton, A. D. & Dexter, T. M. Nature 303, 629–631 (1983).

    Article  CAS  ADS  Google Scholar 

  17. Roberts, R. et al. Nature 332, 376–378 (1988).

    Article  CAS  ADS  Google Scholar 

  18. Wyllie, A. H. Nature 284, 555–557 (1980).

    Article  CAS  ADS  Google Scholar 

  19. Wyllie, A. H., Morris, R. G., Smith, A. L. & Dunlop, D. J. Pathol. 142, 67–77 (1984).

    Article  CAS  Google Scholar 

  20. von Wangenheim, H. R., Schofield, R., Kyffin, S. & Slein, B. Biomedicine 27, 337–340 (1977).

    CAS  PubMed  Google Scholar 

  21. Bronchud, M. H. et al. Br. J. Cancer 58, 64–69 (1988).

    Article  CAS  Google Scholar 

  22. Gabrilove, J. L., Jakubowski, A., Scher, H. et al. New Engl. J. Med. 318, 1414–1422 (1988).

    Article  CAS  Google Scholar 

  23. Tsujimoto, Y., Finger, L. R., Yunis, J. J., Nowell, P. C. & Croce, C. M. Science 226, 1097–1099 (1984).

    Article  CAS  ADS  Google Scholar 

  24. Bakshi, A. et al. Cell 41, 899–906 (1985).

    Article  Google Scholar 

  25. Cleary, M. L., Smith, S. D. & Sklar, J. Cell 47, 19–28 (1986).

    Article  CAS  Google Scholar 

  26. Burgess, A. W., Camakaris, J. & Metcalf, D. J. biol. Chem. 252, 1998–2003 (1977).

    CAS  PubMed  Google Scholar 

  27. Welte, K. et al. Proc. natn. Acad. Sci. U.S.A. 82, 1526–1530 (1985).

    Article  CAS  ADS  Google Scholar 

  28. Liu, Y. J. et al. Nature (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Williams, G., Smith, C., Spooncer, E. et al. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343, 76–79 (1990). https://doi.org/10.1038/343076a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/343076a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing