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The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

Nature volume 342, pages 512–518 (1989)Cite this article

Abstract

The C-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs.

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Author notes

  1. George F. Vande Woude: Bionetics Research Inc., National Cancer Institute, P.O. Box B, Frederick, Maryland 21701, USA

Authors and Affiliations

  1. Tsukuba Life Science Center (RIKEN), Koyadai 3–1–1, Tsukuba, Ibaraki, 305, Japan

    Noriyuki Sagata, Nobumoto Watanabe, George F. Vande Woude & Yoji Ikawa

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  1. Noriyuki Sagata
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  2. Nobumoto Watanabe
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  3. George F. Vande Woude
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  4. Yoji Ikawa
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Sagata, N., Watanabe, N., Vande Woude, G. et al. The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs. Nature 342, 512–518 (1989). https://doi.org/10.1038/342512a0

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