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Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

Nature volume 342, pages 505–511 (1989)Cite this article

Abstract

The Xenopus c-mos proto-oncogene product, pp39mos, accumulates in the unfertilized egg during maturation, is hyperphosphorylated and exhibits protein kinase activity. On fertilization, or soon after the completion of meiosis, the accumulated pp39mos undergoes selective proteolysis. Using an in vitro protease assay system, we show here that this specific proteolysis is caused by the calcium-dependent cysteine protease, calpain.

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Author notes

  1. George F. Vande Woude: Bionetics Research Inc., National Cancer Institute, P.O. Box B, Frederick, Maryland 21701, USA

Authors and Affiliations

  1. Tsukuba Life Science Center Riken, Koyadai 3-1-1, Tsukuba, Ibaraki, 305, Japan

    Nobumoto Watanabe, George F. Vande Woude, Yoji Ikawa & Noriyuki Sagata

Authors
  1. Nobumoto Watanabe
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  2. George F. Vande Woude
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  3. Yoji Ikawa
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  4. Noriyuki Sagata
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Watanabe, N., Vande Woude, G., Ikawa, Y. et al. Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs. Nature 342, 505–511 (1989). https://doi.org/10.1038/342505a0

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