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The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

Abstract

The herpes simplex virus transactivator VP16 par-ticipates in the formation of a multiprotein-DNA complex with the ubiquitous octamer-motif-binding factor Oct-1. Complex formation is dependent on specific amino acids in the Oct-1 homoeodomain which are in positions analogous to positive control mutations in helix 2 of the λ phage repressor helix-turn-helix motif, indicating that this structure is an ancient target for protein-protein interactions mediating transcriptional control.

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Stern, S., Tanaka, M. & Herr, W. The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature 341, 624–630 (1989). https://doi.org/10.1038/341624a0

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  • DOI: https://doi.org/10.1038/341624a0

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