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Expression of a large family of POU-domain regulatory genes in mammalian brain development

Nature volume 340, pages 35–42 (1989)Cite this article

A Correction to this article was published on 24 August 1989

Abstract

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

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Authors and Affiliations

  1. Howard Hughes Medical Institute,

    Donna M. Simmons, Holly A. Ingraham, Larry W. Swanson & Michael G. Rosenfeld

  2. Eukaryotic Regulatory Biology Program, Center for Molecular Genetics, School of Medicine, University of California, San Diego

    Xi He, Maurice N. Treacy, Holly A. Ingraham & Michael G. Rosenfeld

  3. Department of Biology, Center for Molecular Genetics, School of Medicine, University of California, San Diego, USA

    Xi He

  4. The Salk Institute for Biological Studies, La Jolla, California, 92136-9216, USA

    Donna M. Simmons & Larry W. Swanson

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  1. Xi He
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  2. Maurice N. Treacy
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He, X., Treacy, M., Simmons, D. et al. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 340, 35–42 (1989). https://doi.org/10.1038/340035a0

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