Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Expression of a large family of POU-domain regulatory genes in mammalian brain development

Nature volume 340, pages 35–42 (1989)Cite this article

A Correction to this article was published on 24 August 1989

Abstract

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Dodd, J. & Jessell, T. M. Science 242, 682–699 (1988).

    ADS  Article  Google Scholar 

  2. Harrelson, A. L. & Goodman, C. S. Science 242, 700–708 (1988).

    ADS  CAS  Article  Google Scholar 

  3. Scott, M. P. & Carroll, S. B. Cell 51, 689–698 (1987).

    CAS  Article  Google Scholar 

  4. Gehring, W. J. Science 236, 1245–1252 (1987).

    ADS  CAS  Article  Google Scholar 

  5. Ingham, P. W. Nature 335, 25–34 (1988).

    ADS  CAS  Article  Google Scholar 

  6. Akam, E. Development 101, 1–22 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Scott, M. P. & Weiner, A. J. Proc. natn. Acad. Sci. U.S.A. 81, 4115–4119 (1984).

    ADS  CAS  Article  Google Scholar 

  8. McGinnis, W., Levine, M., Hafen, E., Kuroiwa, A. & Gehring, W. J. Nature 308, 428–433 (1984).

    ADS  CAS  Article  Google Scholar 

  9. Scott, M. P., Tamkin, J. W. & Hatzell, G. W. BBA Rev. Cancer (in the press).

  10. Hoey, T. & Levine, M. Nature 332, 858–861 (1988).

    ADS  CAS  Article  Google Scholar 

  11. Beachy, P. A., Krasnow, M. A., Gavis, E. R. & Hogness, D. S. Cell 55, 1069–1081 (1988).

    CAS  Article  Google Scholar 

  12. Jaynes, J. B. & O'Farrell, P. H. Nature 336, 744–749 (1988).

    ADS  CAS  Article  Google Scholar 

  13. Desplan, C., Theis, J. & O'Farrell, P. H. Cell 54, 1081–1090 (1988).

    CAS  Article  Google Scholar 

  14. Han, K., Levine, M. & Manley, J. Cell 56, 573–583 (1989).

    CAS  Article  Google Scholar 

  15. Carrasco, A. E., McGinnis, W., Gehring, W. J. & DeRobertis, E. M. Cell 37, 408–414 (1984).

    Article  Google Scholar 

  16. Holland, P. & Hogan, B. Genes Dev. 2, 773–782 (1988).

    CAS  Article  Google Scholar 

  17. Martin, G. R. et al. Nature 325, 21–22 (1987).

    ADS  CAS  Article  Google Scholar 

  18. Ingraham, H. A. et al. Cell 55, 519–529 (1988).

    CAS  Article  Google Scholar 

  19. Bodner, M. et al. Cell 55, 505–518 (1988).

    CAS  Article  Google Scholar 

  20. Ko, H. S., Fast, P., McBride, W. & Staudt, L. M. Cell 55, 135–144 (1988).

    CAS  Article  Google Scholar 

  21. Muller, M. M., Ruppert, S., Schaffner, W. & Matthias, P. Nature 236, 544–551 (1988).

    ADS  Article  Google Scholar 

  22. Clerc, R. G., Corcoran, L. M., LeBowitz, J. H., Baltimore, D. & Sharp, P. A. Genes Dev. 2, 1570–1581 (1988).

    CAS  Article  Google Scholar 

  23. Scheidereit, C. et al. Nature 336, 551–557 (1988).

    ADS  CAS  Article  Google Scholar 

  24. Sturm, R. A., Das, G. & Herr, W. Genes Dev. 2, 1582–1599 (1988).

    CAS  Article  Google Scholar 

  25. Mangalam, H. J. et al. Genes Dev. (in the press).

  26. Finney, M., Ruvkun, G. & Horvitz, H. R. Cell 55, 757–769 (1988).

    CAS  Article  Google Scholar 

  27. Chalfie, M., Horvitz, H. R. & Sulston, J. E. Cell 24, 59–69 (1981).

    CAS  Article  Google Scholar 

  28. Herr, W. et al. Genes Dev. 2, 1513–1516 (1988).

    CAS  Article  Google Scholar 

  29. Robertson, M. Nature 336, 522–524 (1988).

    ADS  CAS  Article  Google Scholar 

  30. Saiki, R. K. et al. Science 239, 487–491 (1988).

    ADS  CAS  Article  Google Scholar 

  31. Doe, C. Q., Hiromi, Y., Gehring, W. J. & Goodman, C. S. Science 239, 170–175 (1988).

    ADS  CAS  Article  Google Scholar 

  32. Berry, M. in Studies of the Development of Behavior and the Nervous System (Academic, New York, 1974).

    Google Scholar 

  33. Rakic, P. in Organization of the Cerebral Cortex (MIT Press, Cambridge, 1981).

    Google Scholar 

  34. Dony, C. & Gross, P. EMBO J. 6, 2965–2975 (1987).

    CAS  Article  Google Scholar 

  35. Augulewitsch, A., Utset, M. F., Hart, C. P., McGinnis, W. & Ruddle, F. H. Nature 320, 328–335 (1986).

    ADS  Article  Google Scholar 

  36. Gaunt, S. J. Development 101, 51–60 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Holland, P. & Hogan, B. Nature 321, 251–253 (1986).

    ADS  CAS  Article  Google Scholar 

  38. Krumlauf, R., Holland, P., McVey, H. H. & Hogan, B. Development 99, 603–617 (1987).

    CAS  PubMed  Google Scholar 

  39. Odenwald, W. F. et al. Genes Dev. 1, 482–496 (1987).

    CAS  Article  Google Scholar 

  40. Blochlinger, K., Bodner, R., Jack, J., Jan, L. Y. & Jan, Y. N. Nature 333, 629–635 (1988).

    ADS  CAS  Article  Google Scholar 

  41. Tomlinson, A., Kimmel, B. E. & Rubin, G. M. Cell 55, 771–784 (1988).

    CAS  Article  Google Scholar 

  42. Way, J. C. & Chalfie, M. Cell 54, 5–16 (1988).

    CAS  Article  Google Scholar 

  43. Chalfie, M. & Au, M. Science 243, 1027–1033 (1989).

    ADS  CAS  Article  Google Scholar 

  44. Sanger, F., Nicklen, S. & Carlson, A. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    ADS  CAS  Article  Google Scholar 

  45. Simmons, D. M., Arriza, J. & Swanson, L. W. J. Histotech. (in the press).

  46. Crenshaw, III E. B. et al. Genes Dev. (in the press).

Download references

Author information

Affiliations

  1. Howard Hughes Medical Institute

    Donna M. Simmons, Holly A. Ingraham, Larry W. Swanson & Michael G. Rosenfeld

  2. Eukaryotic Regulatory Biology Program, Center for Molecular Genetics, School of Medicine, University of California, San Diego

    Xi He, Maurice N. Treacy, Holly A. Ingraham & Michael G. Rosenfeld

  3. Department of Biology, Center for Molecular Genetics, School of Medicine, University of California, San Diego, USA

    Xi He

  4. The Salk Institute for Biological Studies, La Jolla, California, 92136-9216, USA

    Donna M. Simmons & Larry W. Swanson

Authors
  1. Xi He
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maurice N. Treacy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Donna M. Simmons
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Holly A. Ingraham
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Larry W. Swanson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Michael G. Rosenfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

He, X., Treacy, M., Simmons, D. et al. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 340, 35–42 (1989). https://doi.org/10.1038/340035a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/340035a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing