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Expression of a large family of POU-domain regulatory genes in mammalian brain development

A Correction to this article was published on 24 August 1989

Abstract

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

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He, X., Treacy, M., Simmons, D. et al. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 340, 35–42 (1989). https://doi.org/10.1038/340035a0

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