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Structural parts involved in activation and inactivation of the sodium channel

Nature volume 339, pages 597–603 (1989)Cite this article

Abstract

Structure–function relationships of the sodium channel expressed inXenopus oocytes have been investigated by the combined use of site–directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage–sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

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Authors and Affiliations

  1. Max-Planck-lnstitut für biophysikalische Chemie, D-3400, Göttingen, FRG

    Walter Stühmer, Harukazu Suzuki & Xiaodong Wang

  2. Istituto di Cibernetica e Biofisica, CNR, 1-16146, Genova, Italy

    Franco Conti

  3. Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Masaharu Noda, Naoki Yahagi, Hideo Kubo & Shosaku Numa

  4. Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Harukazu Suzuki

Authors
  1. Walter Stühmer
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  2. Franco Conti
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  3. Harukazu Suzuki
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  4. Xiaodong Wang
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  5. Masaharu Noda
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  6. Naoki Yahagi
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  7. Hideo Kubo
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  8. Shosaku Numa
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Stühmer, W., Conti, F., Suzuki, H. et al. Structural parts involved in activation and inactivation of the sodium channel. Nature 339, 597–603 (1989). https://doi.org/10.1038/339597a0

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