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The Drosophila gene torso encodes a putative receptor tyrosine kinase

Nature volume 338, pages 478–483 (1989)Cite this article

Abstract

The maternal gene torso, required for determination of anterior and posterior terminal structures in the Drosophila embryo, was cloned using P-element tagging. Genetic evidence suggests that the action of the gene product is spatially restricted to the terminal regions; the torso messenger RNA, however, is evenly distributed. Structural similarities of the predicted torso protein with growth-factor receptor tyrosine kinases suggest that the spatial restriction of torso activity results from a localized activation of the torso protein at the anterior and posterior egg pole.

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References

  1. Nüsslein-Volhard, C., Frohnhöfer, H. G. & Lehmann, R. Science 238, 1675–1681 (1987).

    ADS  Article  Google Scholar 

  2. Schüpbach, T. & Wieschaus, E. Wilhelm Roux Arch. dev. Biol. 195, 302–317 (1986).

    Article  Google Scholar 

  3. Degelmann, A., Hardy, P. A., Perrimon, N. & Mahowald, A. P. Devl Biol. 115, 479–489 (1986).

    CAS  Article  Google Scholar 

  4. Perrimon, N., Mohler, D., Engstrom, L. & Mahowald, A. P. Genetics 113, 695–712 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Perrimon, N., Engstrom, L. & Mahowald, A. P. Devl Biol. 110, 480–491 (1985).

    CAS  Article  Google Scholar 

  6. Strecker, T. R., Merriam, J. R. & Lengyel, J. A. Development 102, 721–734 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Klingler, M., Erdelyi, M., Szabad, J. & Nüsslein-Volhard, C. Nature 335, 275–277 (1988).

    ADS  CAS  Article  Google Scholar 

  8. Searles, L. L., Jokerst, R. S., Bingham, P., Voelker, R. A. & Greenleaf, A. L. Cell 31, 585–592 (1982).

    CAS  Article  Google Scholar 

  9. Goldberg, D. A., Posakony, J. W. & Maniatis, T. Cell 34, 59–73 (1983).

    CAS  Article  Google Scholar 

  10. Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. & Noll, M. Cell 47, 735–746 (1986).

    CAS  Article  Google Scholar 

  11. Kobayashi, S., Mizuno, H. & Okada, M. Devl Growth Differ. 30, 251–260 (1988).

    Article  Google Scholar 

  12. Hultmark, D., Klemenz, R. & Gehring, W. J. Cell 44, 429–438 (1986).

    CAS  Article  Google Scholar 

  13. Breathnach, R. & Chambon, P. A. Rev. Biochem. 50, 349–383 (1981).

    CAS  Article  Google Scholar 

  14. Fitzgerald, M. & Shenk, T. Cell 24, 251–260 (1981).

    CAS  Article  Google Scholar 

  15. Cavener, D. R. Nucleic Acids Res. 15, 1353–1361 (1987).

    CAS  Article  Google Scholar 

  16. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982).

    CAS  Article  Google Scholar 

  17. Klein, P., Kanehisa, M. & DeLisi, C. Biochim. biophys. Acta 815, 468–476 (1985).

    CAS  Article  Google Scholar 

  18. Heijne, G.v. J. molec. Biol. 184, 99–105 (1985).

    Article  Google Scholar 

  19. Heijne, G.v. Nucleic Acids Res. 14, 4683–4690 (1986).

    Article  Google Scholar 

  20. Kamps, M. P. & Sefton, B. M. Molec. cell. Biol. 6, 751–757 (1986).

    CAS  Article  Google Scholar 

  21. Takahashi, M. & Cooper, G. M. Molec. cell. Biol. 7, 1378–1385 (1987).

    CAS  Article  Google Scholar 

  22. Hirai, H., Maru, Y., Hagiwara, K., Nishida, J. & Takaku, F. Science 238, 1717–1720 (1987).

    ADS  CAS  Article  Google Scholar 

  23. Yarden, Y. & Ullrich, A. A. Rev. Biochem. 57, 443–478 (1988).

    CAS  Article  Google Scholar 

  24. Hunter, T. & Cooper, J. A. A. Rev. Biochem. 54, 897–930 (1985).

    CAS  Article  Google Scholar 

  25. Basler, K. & Hafen, E. Trends Genetics 4, 74–79 (1988).

    CAS  Article  Google Scholar 

  26. Brower, D. L., Smith, R. J. & Wilcox, M. Nature 285, 403–405 (1980).

    ADS  CAS  Article  Google Scholar 

  27. Schüpbach, T. Cell 49, 699–707 (1987).

    Article  Google Scholar 

  28. Anderson, K. V., Jürgens, G. & Nüsslein-Volhard, C. Cell 42, 779–789 (1985).

    CAS  Article  Google Scholar 

  29. Hashimoto, C., Hudson, K. L. & Anderson, K. V. Cell 52, 269–279 (1988).

    CAS  Article  Google Scholar 

  30. Anderson, K. V., Bokla, L. & Nüsselein-Volhard, C. Cell 42, 791–798 (1985).

    CAS  Article  Google Scholar 

  31. Nishida, Y. et al. EMBO J. 7, 775–781 (1988).

    CAS  Article  Google Scholar 

  32. Mark, G. E., MacIntyre, R. J., Digan, M. E., Ambrosio, L. & Perrimon, N. Molec. cell. Biol. 7, 2134–2140 (1987).

    CAS  Article  Google Scholar 

  33. Bonner, T. I. et al. Nucleic Acids Res. 14, 1009–1015 (1986).

    CAS  Article  Google Scholar 

  34. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: a Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  35. Ingham, P. W., Howard, K. R. & Ish-Horowicz, D. Nature 318, 439–445 (1985).

    ADS  CAS  Article  Google Scholar 

  36. King, R. C. Ovarian Development in Drosophila melanogaster (Academic, New York, 1970).

    Google Scholar 

  37. Bause, E. Biochem. J. 209, 331–336 (1983).

    CAS  Article  Google Scholar 

  38. Sanger, F., Nicklen, S. & Coulson, R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    ADS  CAS  Article  Google Scholar 

  39. Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).

    ADS  CAS  Article  Google Scholar 

  40. Anderson, S. K., Gibbs, C. P., Tanaka, H.-J. K. & Fujita, D. J. Molec. cell. Biol. 5, 1122 (1985).

    CAS  Article  Google Scholar 

  41. Livneh, E., Glazer, L., Segal, D., Schlesinger, J. & Shilo, B.-Z. Cell 40, 599–607 (1985).

    CAS  Article  Google Scholar 

  42. Yarden, Y. et al. Nature 323, 226–232 (1986).

    ADS  CAS  Article  Google Scholar 

  43. Bairoch, A. & Claverie, J. M. Nature 331, 22 (1988).

    ADS  CAS  Article  Google Scholar 

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Author information

Affiliations

  1. Max-Planck-lnstitut für Entwicklungsbiologie, Abteilung Genetik, Spemannstr. 35/III, D-7400, Tübingen, FRG

    Frank Sprenger, Leslie M. Stevens & Christiane Nüsslein-Volhard

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  1. Frank Sprenger
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  2. Leslie M. Stevens
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  3. Christiane Nüsslein-Volhard
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Sprenger, F., Stevens, L. & Nüsslein-Volhard, C. The Drosophila gene torso encodes a putative receptor tyrosine kinase. Nature 338, 478–483 (1989). https://doi.org/10.1038/338478a0

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